|
|||||
|
|
Central sympathetic reactivity inhibited by indoramin |
|
| Authors: | Meredith Davison Michael Koss |
| Affiliation: | 1. Basic Science Department, Oklahoma College of Osteopathic Medicine and Surgery, P.O. Box 2280, Tulsa, Oklahoma 74101, U.S.A.;7. Department of Pharmacology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, U.S.A. |
| Abstract: | The action of indoramin on central autonomic activity was investigated using the sympathetic-cholinergic electrodermal response system. Indoramin (0.33–10 mg/kg, i.v.) significantly reduced the amplitude of electrodermal responses (EDR) evoked by stimulation of the hypothalamus in a dose-related manner. The CNS effects of indoramin on the EDR were partially antagonized by yohombine pretreatment. These results demonstrate that indoramin reduces central sympathetic reactivity and suggest that an α-adrenergic inhibitory mechanism may be involved. |
| Keywords: | Electrodermal responses Indoramin Yohimbinel Hypothalamus |
| 本文献已被 ScienceDirect 等数据库收录！ | |