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Effects of electrical stimulation on teh enkephalinsin guinea-pig small intestine |
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| Authors: | Alistair D. Corbett Roberto P. Sosa Alexander t. McKnight Hans W. Kosterlitz |
| Affiliation: | Unit for Research on Addictive Drugs, University of Aberdeen, Marischal College, Aberdeen, AB9 1AS, U.K. |
| Abstract: | When myenteric plexus-longitudnal muscle preparations of the guinea-pig small intestine are simulated electrically in the presence of cycloheximide there is a decrease in teh content of enkephalins which is taken to be due to their release. With supramaximal stimuli, the release per pulse is similar at 1 and 10 Hz but it is lower with submaximal than with maximal stimuli. Met-enkephalin is more readily released than Leu-enkephalin. |
| Keywords: | Cycloheximide Electrical stimulation Leu-Enkephalin Met-Enkephalin Myenteric plexus Release |
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