Time course of apomorphine-induced circling behaviour after striatal dopamine receptor denervation |
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Authors: | Claude Oberlander Claude Dumont Jacques R. Boissier |
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Affiliation: | Centre de Recherches Roussel-Uclaf, 93230 Romainville, France |
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Abstract: | The curve describing the time course of apomorphine-induced circling behaviour in rats with a 6-hydroxy-dopamine-induced lesion of the nigrostriatal dopamine (DA) pathway was studied with a microcomputerized rotometer. Up to a 2-week interval after lesioning, the contralateral circling response was a single bell-shaped curve but this gradually became a double-peaked curve after 4–5 months. At this time bell-shaped curve was, however, restored by haloperidol pretreatment. It is concluded that the response of striatal DA receptors was modified either by the lesion of another neuronal system and/or that the absence of DA nerve endings induced changes in the striatal DA receptor itself. |
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Keywords: | Denervated DA receptor Apomorphine Striatum Rotometer Circling behaviour |
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