应用组织速度成像和组织追踪法评价川崎病患儿左心功能

目的应用定量组织速度成像和组织追踪法评价恢复期川崎病患儿左心功能状况。方法恢复期川崎病患儿30例(患病组)，正常儿童20例(正常组)。通过M型超声获得左室射血分数(LVEF)，通过二尖瓣口血流频谱获得二尖瓣口血流快速充盈速度(E)，左房收缩期速度(A)，计算E／A；应用定量组织速度成像和组织追踪分析软件测量心脏前间隔、后壁、前壁、下壁、后间隔和侧壁的二尖瓣环处收缩期峰值速度(Vs)、收缩期最大位移(D)、舒张早期峰值速度(Ve)、左房收缩期峰值速度(Va)，计算Ve／Va。并比较两组间各参数。结果患病组LVEF、E峰、A峰及E／A都在正常范围内，与正常组相比无统计学差异；各室壁的二尖瓣环处的Vs和D两组间差异有显著性意义，6个室壁的平均Vs和D两组间差异也有有显著性意义；各室壁的舒张速度Ve和Va以及Ve／Va，只在少数室壁两组间差异有显著性意义。结论川崎病恢复期左室整体收缩功能受损，舒张功能尚正常；组织速度成像技术能够定量评价小儿纵向左室功能改变。

Assessment of left ventricular function in children with convalescent Kawasaki disease by quantitative tissue velocity imaging and tissue tracking

Objective To assess the left ventricular(LV) function in children with convalescent Kawasaki disease (KD) by quantitative tissue velocity imaging(QTVI) and tissue tracking(TT).Methods Twenty healthy subjects and thirty children with convalescent KD were studied by QTVI and TT.Off-line LV regional velocity and displacement profiles along LV apical long-axis view,apical two-chamber view and four-chamber view were obtained synchronously.The peak systolic displacement (D) and the peak velocities of systolic (Vs) and early diastole (Ve) and artrial contraction (Va) from posteroseptal,lateral,anteroseptal,posterior,anterior and inferior wall were measured and the Ve/Va was calculated.Transmitral flow velocities during early diastole(E) and artrial contraction(A) were also measured by Doppler echocardiography and the E/A was calculated too.Results The Vs and displacement of every wall at mitral annunal level was lower in KD children than that in healthy children (P< 0.05); There was significant difference in Ve,Va and Ve/Va at several wall between KD children and healthy children; There was no significant difference in E,A and E/A between the two groups.Conclusions The left ventricular longitudinal systolic function is impaired although left ventricular ejection fraction is normal and diastolic funtion is almost normal in convalescent KD children.