| 脑梗死后血、脑脊液中兴奋性氨基酸变化与神经功能缺失的关系 |
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| 引用本文： | 张中兴,卢红,张萍,宋景贵,张帆,刘麦仙.脑梗死后血、脑脊液中兴奋性氨基酸变化与神经功能缺失的关系[J].中国组织工程研究与临床康复,2003,7(25):3422-3423. |
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| 作者姓名： | 张中兴 卢红 张萍 宋景贵 张帆 刘麦仙 |
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| 作者单位： | 新乡医学院第二附属医院神经内科,河南省新乡市,453002 |
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| 基金项目： | 河南省教育厅资助项目(98320025)~~ |
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| 摘 要： | 目的:观察脑梗死患者血和脑脊液(CSF)中兴奋性氨基酸浓度的动态变化,并探讨其变化规律及临床意义。方法:采用高效液相色谱法检测了32例正常对照组和86例脑梗死患者起病后6h～10d的血及CSF中谷氨酸(Glu)和甘氨酸(Gly)浓度的变化。结果:脑梗死组Glu和Gly的浓度在6h后已开始升高,24h明显升高犤CSF中Glu(62.8±25.9)μmol/L,t=4.71,P<0.01,Gly(82.1±24.5)μmol/L,t=3.52,P<0.01;血中Glu(134.1±25.3)μmol/L,t=3.07,P<0.05,Gly(195.1±27.1)μmol/L,t=3.03,P<0.05犦。二三天达高峰犤CSF中,Glu(78.1±14.2)μmol/L,t=7.26,P<0.01,Gly(106.0±26.3)μmol/L,t=5.95,P<0.01;血中Glu(146.3±6.4)μmol/L,t=14.43,P<0.01,Gly(248.1±12.5)μmol/L,t=16.69,P<0.01犦。3d后渐下降,7～10d后基本接近正常。同时还发现脑梗死后血及CSF中Glu浓度呈正相关(r=0.826,P<0.01)。CSF中Glu浓度的变化与梗死灶的直径和神经功能缺失评分也呈正相关(r=0.628,P<0.01,r=0.718,P<0.01),而与病程呈抛物线型相关(3d前r=0.806,P<0.01呈显著正相关,3d后r=-0.382,P<0.05呈负相关)。结论:动态观察血和CSF中Glu和Gly的浓度变化,可作为临床观察病情变化和判断预后的敏感指标。
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| 关 键 词： | 脑梗塞 兴奋性氨基酸类 血 脑脊髓液 色谱法 高压液相 |
| 文章编号： | 1671-5926(2003)25-3422-02 |
| 修稿时间： | 2003年4月2日 |
The relation between dynamic changes of excitatory amino acids in blood and cere brospinal fluid and neurological functional defect in patients with cerebral inf arction |
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| Zhong-Xing Zhang,Hong Lu,Ping Zhang,Jing-Gui Song,Fan Zhang,Mai-Xian LiuZhong-Xing Zhang,Hong Lu,Ping Zhang,Jing-Gui Song,Fan Zhang,Mai-Xian Liu,D epartment of Neurology,Second Affiliated Hospital of Xinxiang Medical Collage.The relation between dynamic changes of excitatory amino acids in blood and cere brospinal fluid and neurological functional defect in patients with cerebral inf arction[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2003,7(25):3422-3423. |
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| Authors: | Zhong-Xing Zhang Hong Lu Ping Zhang Jing-Gui Song Fan Zhang Mai-Xian LiuZhong-Xing Zhang Hong Lu Ping Zhang Jing-Gui Song Fan Zhang Mai-Xian Liu D epartment of Neurology Second Affiliated Hospital of Xinxiang Medical Collage |
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| Abstract: | |
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| Keywords: | The Glu and Gly play the important roles in the pathologic process of cerebral infarction The concentrations of Glu and Gly in blood and CSF are t he sensitive index for the clinical observation and diagnosing the prognosis of the diseases |
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