| 系统性红斑狼疮患者血清转化生长因子β_1的含量变化 |
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| 引用本文： | 何宪章,郭晓兰,严明生,凡瞿明,张国元.系统性红斑狼疮患者血清转化生长因子β_1的含量变化[J].川北医学院学报,2003,18(3):87-88. |
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| 作者姓名： | 何宪章 郭晓兰 严明生 凡瞿明 张国元 |
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| 作者单位： | 1. 遂宁市人民医院,四川,遂宁,629000
2. 川北医学院附院风湿免疫研究所,四川,南充,637000 |
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| 摘 要： | 目的探讨系统性红斑狼疮(SLE)患者血清转化生长因子pl(TGF-81)的含量变化及意义。方法采用双抗体夹心ELISA法检测健康人和SLE患者血清TGF-β_1含量,并分析其与临床相关实验室指标的关系。结果 SLE患者血清中TGF-β_1水平显著低于对照组(P<0.01),但与SLE的其它实验室指标无相关关系,缓解期与活动期SLE患者TGF-β_1水平差异无显著性(P>0.05)。结论 SLE患者血清TGF-β_1水平较正常对照组降低,提示其低水平可能与SLE的发生有关,但它并不能判别SLE的活动程度。
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| 关 键 词： | 系统性红斑狼疮 转化生长因子β_1 ELISA |
| 文章编号： | 1005-3697(2003)03-0087-02 |
| 修稿时间： | 2003年7月18日 |
Changes of transforming growth factorβ1 in patients with systemic Lupus Erythematosus |
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| HE Xian-zhang,GUO Xiao-lan,YAN Ming-sheng,FAN Qu-ming,ZHANG Guo-yuan.Changes of transforming growth factorβ1 in patients with systemic Lupus Erythematosus[J].Journal of North Sichuan Medical College,2003,18(3):87-88. |
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| Authors: | HE Xian-zhang GUO Xiao-lan YAN Ming-sheng FAN Qu-ming ZHANG Guo-yuan |
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| Abstract: | Objective To observe the changes of transforming growth factorβ1 in patients with systemic lupus erythematousus(SLE) .Methods TGF -β1 in sera of patients with SLE and healthy people were measured by ELISA. Then compared the relation with other clinical index. Results The levels of TGF-β1 in patients with SLE were more lower than those in control(P < 0.01) ,but had no relations with other index. Conclusion TGF-β1 in patients with SLE were lower than control, which may indicate the occurrenc of SLE if it rise up in serum, but with no judgement to its activity. |
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| Keywords: | ELISA |
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