| 眼睑恶性肿瘤发病的分子机制 |
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| 引用本文： | 刘夫玲,牛膺筠. 眼睑恶性肿瘤发病的分子机制[J]. 眼科新进展, 2006, 26(9): 710-712 |
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| 作者姓名： | 刘夫玲 牛膺筠 |
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| 作者单位： | 266003,山东省青岛市,青岛大学医学院附属医院眼科 |
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| 摘 要： | 眼睑恶性肿瘤是眼科常见病,其中眼睑基底细胞癌、鳞状细胞癌及眼睑皮脂腺癌最多见,并称眼睑3大恶性肿瘤。随着分子生物学技术的发展,研究发现多种因素参与眼睑恶性肿瘤发病过程,与其发病有关的癌基因、抑癌基因、细胞凋亡相关基因、细胞增殖相关因子、粘附因子、基底膜蛋白、端粒酶等,这些基因和蛋白的变异与眼睑恶性肿瘤的发生发展、分化程度、浸润转移、预后等密切相关。
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| 关 键 词： | 眼睑恶性肿瘤 发病机制 基因 |
| 文章编号： | 1003-5141(2006)09-0710-03 |
| 收稿时间： | 2005-07-08 |
| 修稿时间： | 2005-11-14 |
Study on the pathogenesis of malignant eyelid neoplasms |
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| LIU Fu-Ling,NIU Ying-Jun. Study on the pathogenesis of malignant eyelid neoplasms[J]. Recent Advances in Ophthalmology, 2006, 26(9): 710-712 |
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| Authors: | LIU Fu-Ling NIU Ying-Jun |
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| Affiliation: | From the Department of Ophthalmologv , Affiliated Hospital, Qi ngdao University Medical College, Qingdao 266003, Shandong Province, China |
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| Abstract: | Malignant eyelid neoplasms are common eye diseases,among which basal cell carcinoma,squamous cell carcinoma,sebaceous carcinoma are most common.With the development of molecularbiology,the research has proved tumor genesis is a coordinative multistep process involving many genes.The activaton of oncogene,inactivaton of anti-oncogene,imbalances of the proliferation and apoptosis genes,cluster of differentiation and telomerase are all involved in the process.All above-mentioned is related to the genesis,development,invasion,metastasis and prognosis of malignant eyelid neoplasms. |
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| Keywords: | eyelid neoplasms pathogenesis gene |
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