大剂量呋塞米联合多巴胺静脉泵入治疗顽固性心力衰竭32例

目的：观察大剂量呋塞米联合多巴胺静脉泵人治疗顽固性心力衰竭的疗效及安全性。方法：将32例常规治疗后心功能Ⅳ级患者，予以呋塞米1600mg／d及多巴胺静脉泵入治疗。治疗前后分别评价氧饱和度、心功能、血压、心率、体重及血清生化指标。结果：大剂量呋塞米静脉持续泵入治疗可显著改善患者症状，使氧饱和度升高，左室射血分数增加，心率、体重及肌酐水平均明显降低（P〈0．01）；常规补充氯化钾及适量补充氯化纳，治疗前后血清钾、钠差异无统计学意义（P〉0．05）。结论：大剂量呋塞米联合多巴胺静脉泵入治疗可以显著改善顽固性心力衰竭症状，安全可靠。

Pumping high dose of furosemide combined with dopamine for treatment of intractable heart failure

Objective：To observe the therapeutic effect and safety of flushing use of furosemide and dopamine in treatment of patients with intractable heart failure. Methods：Thirty two patients with heart function of grade Ⅳ （who had been treated with conventional therapy before） were administered intravenous infusion of 1600 mg/d furosemide and dopamine. The SaO2, heart function, blood pressure,heart rate, body weight and sermn biochemical indicator were analyzed before and after the therapy. Results： Continuous intravenous infusion of flushing dose of furosemide improved the symptoms of the patients ,heightened the SaO2 and the left ventricular ejection fraction, and depressed the heart rate,body weight and serum creatinine level（P 〈 0. 05 ）. Conventional supplement of KCl and NaCl was administered, and the variance of serum levels of kalium and sodium had no statistical significance before and after the treatment （P 〉0. 05 ）. Conclusions： Flushing use of intervenous infusion of furosemide and dopamine can significantly improve the symptoms of the patients. It is safe and reliable.