Meningoencephalitis due to penicillin-resistantStreptococcus pneumoniae |
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Authors: | T. Vassal O. Piot Z. Mallat D. Lesage B. Guidet Prof G. Offenstadt |
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Affiliation: | (1) Service de Réanimation Polyvalente, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, F-75571 Paris, France;(2) Service de Bactériologie-Virologie, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, F-75571 Paris, France |
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Abstract: | The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory level of antibiotic in the cerebrospinal fluid with moderate dosage. In France, as well as in many countries, high doses of third-generation cephalosporins such as cefotaxime or ceftriaxone should be administered for the initial therapy of suspected pneumococcal meningitis. |
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Keywords: | Meningoencephalitis Penicillin-resistantStreptococcus pneumoniae Antibiotics in CSF Cefotaxime |
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