13C-辛酸呼气试验测定肝硬化胃固体排空功能研究

目的:观察13C-辛酸呼气试验测定肝硬化患者胃固体排空功能变化特点。方法:选取43例乙肝肝硬化患者测定胃固体食物排空时间并与10例健康对照者的胃固体食物排空时间进行比较,按Child-pugh分级进行A、B、C 3级之间胃固体排空时间的比较。结果:乙肝肝硬化患者GET1/2和Tlag较健康对照组明显延长(P<0.05);乙肝肝硬化组Child-pugh分级A级与健康对照组GET1/2无统计学差异(P>0.05),B级、C级患者GET1/2较健康对照组明显延长(P<0.05)。结论:肝硬化患者存在胃排空延迟,表现为肝功能Child-pugh评分越高胃排空能力越弱;肝硬化患者Child-pugh A级患者与健康正常者比较胃排空无明显延迟。

Measurement of solid gastric emptying by 13C-octanoic acid breath test in patients with cirrhosis

Objective: To observe the changes of gastric emptying functions in patients with cirrhosis with 13 C-octanoic acid breath test.Methods: Select 43 cases of hepatitis B virus(HBV) related liver cirrhosis and 10 healthy controls.The gastric emptying time of solid food was then measured in both groups and the gastric half-emptying time was compared.Results: The GET 1/2 and Tlag of HBV related liver cirrhosis were prolonged significantly than those of healthy control group(P<0.05).There was no significant difference in GET 1/2 of Child-pugh grade A of HBV related cirrhosis and the control group(P>0.05).Compared with control group,the GET 1/2 of Child-pugh grade B and C was prolonged significantly(P<0.05).Conclusion: There is delayed gastric emptying in patients with cirrhosis,which displays the higher of Child-pugh scores,the weaker of gastric emptying ability.There are not delayed significantly in gastric emptying time in Child-pugh class A patients of HBV related cirrhosis compared with control group.