| 骨髓基质干细胞治疗帕金森病的实验研究 |
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| 引用本文： | 孙兵,惠国桢,杨立业,刘相名,郭礼和. 骨髓基质干细胞治疗帕金森病的实验研究[J]. 实用临床医药杂志, 2003, 7(3): 194-196 |
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| 作者姓名： | 孙兵 惠国桢 杨立业 刘相名 郭礼和 |
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| 作者单位： | 1. 苏州大学附属第一医院,神经外科,江苏,苏州,215007
2. 中国科学院,上海生命科学研究院,生化细胞所,上海,200031 |
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| 基金项目： | 国家自然科学基金资助项目 (3 0 2 713 2 5 )，江苏省自然科学基金资助项目 (BK2 0 0 1170 ) |
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| 摘 要： | 目的 探讨骨髓基质干细胞对帕金森病的疗效。方法 用 6 OHDA破坏SD大鼠一侧黑质 ,建立帕金森病模型 ,采用立体定向仪 ,将BrdU标记的骨髓基质干细胞注入模型鼠患侧的纹状体 ,分别在治疗后 2、4周观察apomorphin诱导的旋转行为的变化 ,并进行脑冰冻切片观察。结果 治疗后 2周帕金森病症状开始改善 ,4周时纹状体中有多巴胺样神经元出现。结论 骨髓基质干细胞是治疗帕金森病理想的供体细胞
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| 关 键 词： | 骨髓基质干细胞 帕金森病 多巴胺神经元 |
| 文章编号： | 1672-2353(2003)03-0194-03 |
| 修稿时间： | 2003-03-15 |
TREATMENT FOR PARKINSON''''s DISEASE WITH PRIMARY RAT BONE MARROW STROMAL CELLS |
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| SUN Bin ,HUI Guo-zhen ,YANG Li-ye ,LIU Xiang-min ,GUO Li-he. TREATMENT FOR PARKINSON''''s DISEASE WITH PRIMARY RAT BONE MARROW STROMAL CELLS[J]. Journal of Clinical Medicine in Practice, 2003, 7(3): 194-196 |
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| Authors: | SUN Bin HUI Guo-zhen YANG Li-ye LIU Xiang-min GUO Li-he |
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| Affiliation: | SUN Bin 1,HUI Guo-zhen 1,YANG Li-ye 1,LIU Xiang-min 1,GUO Li-he 2 |
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| Abstract: | Objective: To investigate theraputic effects of primary bone marrow stromal cells (BMSCs) on Parkinson′s disease. Methods: 6-hydroxydopamine was stereotaxically injected into the lateral substantia nigra to establish Parkinson′s disease model. Following the intrastratial grafts of BrdU-labelled BMSC, therapeutic effects were evaluated by observing the apomorphine-induced rotation. BMSC was pursued by immunochemical assay. Results: Compared with control group, behavioral recovery was significantly improved 2 weeks after. 4 weeks after the treatment, a few TH-positive cells were seen in stratial part. Conclusions: BMSC is a kind of attractive candidate to treat Parkinson′s disease. |
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| Keywords: | bone marrow stromal cell parkinson′s disease dopaminergic neuron |
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