藤茶和荷叶提取物对高脂血症大鼠降血脂作用的实验研究

目的建立高血脂动物模型,观察藤茶和荷叶提取物对高血脂模型大鼠血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、Lee＇s指数的影响.方法用高脂饲料喂养造模后,随机分为模型组、高剂量组20mg/kg、中剂量组10 mg/kg、低剂量组5 mg/kg及降脂药物组180 mg/kg,连续给药25 d.观察：①TC、TG、HDL-C;②体重变化;③肝重/体重比;④体脂湿重测定;⑤Lee＇s指数.结果各剂量实验组TC、TG和HDL值与模型组及降脂药物组比较差别无显著性（P＞0.05）;但中剂量和高剂量实验组与实验前比较TC值有显著降低（P＜0.05）,高剂量组与模型组比较,Lee＇s指数下降,差别有显著性（P＜0.05）.结论藤茶和荷叶提取物有降低血清胆固醇和减肥作用.

Antilipemic Effect of Extracts of Ampelopis Grossedentata and Lotus Leaf (EAGLL)on Rats with Hypercholesterolemia

Objective To establish a rat model of hypercholesterolemia,and examine whether oral administration of extracts of Ampelopis grossedentata and Lotus leaf(EAGLL) can reduce level of TC of rat.Methods\ 50 rats of hypercholesterolemia were divided randomly into five groups: low dose group of EAGLL 5 mg/kg,moderate dose group of EAGLL 10 mg/kg,high dose group of EAGLL 20 mg/kg,model control group fed with a high cholesterol diet,medicine group of oral cholesterol-reducing medicine 180 mg/kg.All test groups of were administrated continuously for 28 days.TG,TC,HDL-C,weight,fat and Lee's index were measured.Results\ Blood biochemical analysis showed TC value was lower after EAGLL administration than before in the moderate and high dose groups(P<0.05).Lee's index was lower in high dose group than in model control group(P<0.05).Conclusion\ EAGLL decreased value of cholesterol and Lee's index of rat model of hypercholesterolemia.