超声导引下艾迪注射液及顺铂联合应用治疗恶性胸腔积液

目的:比较艾迪注射液和顺铂及两者联用对恶性胸腔积液的治疗作用。方法:自2003年10月~2008年5月我院肿瘤科收治恶性胸腔积液患者149例,随机分为A、B、C 3组,3组均超声引导下介入穿刺置入中心静脉导管,充分引流后,A组51例,胸腔注入艾迪注射液和顺铂;B组49例,胸腔内注入顺铂;C组49例胸腔内注入艾迪注射液。均每周1次,治疗1~4次不等。结果:有效率(RR),A、B、C 3组分别为:82.4%、49%、55%,A组高于C组和B组,差异具有统计学意义(P<0.05)。生存质量KPS评分有效率:A组高于C组和B组(P<0.05)。毒性评价(Ⅱ级以上):B组>A组>C组。三组两两比较差异有统计学意义(P<0.05)。结论:艾迪注射液联合顺铂疗效优于单用顺铂或艾迪注射液,艾迪注射液优于顺铂。

Minimal-trauma tube installation guided under ultrasonography in treatment of malignant thoracic by intrapleural injection of Aidi and Cisplatin

Objective：To compare the therapeutical effect among Aidi injection ,Cisplatin and Aidi injection associated with Cisplantin for malignant pleural effusions therapy. Methods： From Oct. 2003 to May 2008,149 patients underwent malignant pleural effusion were randomly divided into three groups： A group （51cases）,B group （49cases） and C group （49cases）. All the three groups underwent ultrasound-guided central venous catheter closed drainage. Once a week, with thoroughly drainage, Aidi injection associated with Cisplatin, Cisplatin, Aidi injection was respectively injected into pleural cavity of A, B, C group. Resuits： As to cure rate,there was statistically difference （ P 〈0.05） among group A （82.4%） ,B（49%） and C（55%）. According to survival quality KPS： A〉C（ P d0.05）and C〉B（ P 〈0.05）. According to toxicity evaluation （above Ⅱ）, there was also statistically difference （ P 〈0.05） among A,B and C （A〉B〉C）. Conclusion： Aidi injection associated with Cisplatin is superior to solitary used Aidi injection or Cisplatin,and the efficacy of Aidi injection is superior to Cisplatin.