Genetic basis of multiple sclerosis: HLA antigens, disease progression, and oligoclonal IgG in CSF |
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| Authors: | L. Stendahl-brodin,,H. Link,M.D.,E. Mö ller, E. Norrby |
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| Affiliation: | Departments of Ophthalmology and Neurology, University Hospital, Linköping, Department of Clinical Immunology, Huddinge Hospital, Huddinge and Department of Virology, Karolinska Institutet Medical School, Stockholm, Sweden |
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| Abstract: | The HLA antigens B7 and Dw2 occurred at elevated frequencies in 105 multiple sclerosis (MS) patients (49 and 47%, respectively), compared to healthy controls (29 and 30%), especially in MS patients with oligoclonal CSF-IgG (51 and 50%), in cases with CSF-IgG index values above 1.5 (64 and 64%), and in those with the most malignant course of the disease (47 and 59%). Normal or only slightly elevated frequencies of B7 and Dw2 were found in MS patients without oligoclonal CSF IgG (35 and 29%), normal CSF-IgG index (43 and 39%), and the most benign course (42 and 37%). No correlation was found between the HLA type and measles virus antibody titers in serum or a measles virus antibody response within the CNS. |
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| Keywords: | HLA antigens multiple sclerosis oligoclonal CSF IgG |
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