| 多胺胆固醇缀合物纳米粒作为反义核苷酸传递系统的研究 |
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| 引用本文： | 方崇波,陆小儿,郑厚林.多胺胆固醇缀合物纳米粒作为反义核苷酸传递系统的研究[J].海峡药学,2009,21(10):62-63. |
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| 作者姓名： | 方崇波 陆小儿 郑厚林 |
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| 作者单位： | 浙江宁波市医疗中心李惠利医院,宁波315040 |
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| 摘 要： | 目的研究多胺胆固醇缀合物传递反义核苷酸的能力。方法通过对自制脂质体的载药量、红细胞毒性、M3骨髓瘤细胞的转染实验。结果自制脂质体具有比常规脂质体良好的载药量,并且对红细胞毒性相对偏小,对M3骨髓瘤细胞具有一定的转染能力。结论自制的脂质体具有一定的应用前景。
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| 关 键 词： | 反义核苷酸 转染 脂质体 |
To study cholesterol polyamine conjugates as a delivery system of antisense oligonucleotides |
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| FANG Chong-bo,LU Xiao-er,ZHENG Hou-lin.To study cholesterol polyamine conjugates as a delivery system of antisense oligonucleotides[J].Strait Pharmaceutical Journal,2009,21(10):62-63. |
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| Authors: | FANG Chong-bo LU Xiao-er ZHENG Hou-lin |
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| Institution: | (Zhejiang Ningbo medical centre Li hui-li Hospital, Ningbo 315040, China) |
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| Abstract: | OBJECTIVE To study cholesterol polyamine conjugates of antisense oligonucleotides transmission capacity.METHODS Through the self-made liposome drug loading,red blood cell toxicity,M3 myeloma cell transfection experiments.RESULTS The self-made liposomes has contained a good amount of drugs,and relatively low toxicity on the red blood cells,a good capacity of M3 myeloma cells transfected than conventional liposomes.CONCLUSION The self-made liposomes have a good apply perspective. |
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| Keywords: | Antisense oligonucleotides Transfection liposomes |
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