Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial |
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| Affiliation: | 1. Department of Operating Room Nursing, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran;2. Department of Operating Room Technology, School of Paramedicine, Qom University of Medical Sciences, Qom, Iran;3. Student Research Committee, Department of Surgical Technology, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Nursing, School of Nursing and Midwifery, Dezful University of Medical Sciences, Dezful, Iran;5. Department of Oncology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran;6. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Anesthesiology, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran;8. Department of Nursing, Fasa University of Medical Sciences, Fasa, Iran;1. Servicio de Medicina Preventiva, Hospital Universitario Central de Asturias, Oviedo, España;2. Departamento de Medicina, Área de Medicina Preventiva y Salud Pública, Universidad de Oviedo, Oviedo, España;1. Clinical Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea;2. Future Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea;3. Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27710, USA;1. State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;2. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, China;3. Brain Research Institute, Jeffrey Cheah School of Medicine and Health Science, Monash University Malaysia, Bandar Sunway 47500, Malaysia;1. School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia;2. Pharmacy Department, Royal Perth Hospital, Perth, Australia;1. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran;2. Orthopedic Department, Shiraz University of Medical Sciences, Shiraz, Iran;3. Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran;4. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;5. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;6. Research Center for Psychiatry and Behavior Science, Shiraz University of Medical Sciences, Shiraz, Iran;7. Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;8. Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran;9. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran;10. Department of Persian Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran;1. Department of Pharmacy Practice, Al Shifa College of Pharmacy, Kerala University of Health Sciences, Kerala, India;2. Department of Pharmacy, Zulekha Hospital, Dubai, United Arab Emirates |
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| Abstract: | Background and purposeChemotherapy-induced phlebitis (CIP) is one of the most important and common complications in patients with cancer. Currently, the use of complementary methods to prevent or alleviate phlebitis symptoms has attracted great attention. In this study, we aimed to assess the effects of topical sesame oil in reducing the pain severity of CIP.Materials and methodsThis randomized clinical trial was conducted on 60 patients with colorectal cancer afflicted with CIP. Patients received, twice a day for seven consecutive days, a 5-min massage solely (as the control group) or with 10 drops of sesame oil (as the experimental group) within the 10 cm radius of the affected site. The pain severity was evaluated by the visual analog scale on the first, third, fifth, and seventh days of the intervention.ResultsMean changes of the pain severity compared to the baseline were significant on the third (P = 0.009), fifth (P < 0.001), and seventh (P < 0.001) days of the intervention in favor of the experimental group. Also, a significant reduction in the pain severity both in the experimental and control groups was observed during the seven days (F = 720.66, Ptime < 0.001); however, the decrease was more significant in the experimental group (F = 21.46, Pgroup < 0.001).ConclusionApplication of massage with sesame oil as a complementary method is effective in reducing the pain severity of patients with CIP. |
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