| 新腎上腺素能β-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成 |
| |
| 引用本文： | 陈志豪,嵇汝运. 新腎上腺素能β-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成[J]. 药学学报, 1965, 12(9): 623-624 |
| |
| 作者姓名： | 陈志豪 嵇汝运 |
| |
| 作者单位： | 中国科学院药物研究所,上海 |
| |
| 摘 要： | Bromination of 6-acetyl-1,4-benzodioxane gave 6-(α-bromoacetyl)-1,4-benzodioxane (IVb), which was condensed with isopropylamine, forming 6-(α-isopropylaminoacetyl)- 1,4-benzodioxane (IVc). The latter compound afforded the desired aminoethanol (III) upon reduction with potassium borohydride.Pharmacological examinations revealed that III was more potent in adrenergic beta-blocking effect, but was less toxic in comparison with pronethalol.
|
| 收稿时间： | 1965-03-01 |
THE SYNTHESIS OF A NEW ADRENERGIC BETA-RECEPTORBLOCKING AGENT 6-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)-1,4-BENZODIOXANE |
| |
| CHEN CHI-HAO KYI ZU-YOONG. THE SYNTHESIS OF A NEW ADRENERGIC BETA-RECEPTORBLOCKING AGENT 6-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)-1,4-BENZODIOXANE[J]. Acta pharmaceutica Sinica, 1965, 12(9): 623-624 |
| |
| Authors: | CHEN CHI-HAO KYI ZU-YOONG |
| |
| Abstract: | Bromination of 6-acetyl-1,4-benzodioxane gave 6-(α-bromoacetyl)-1,4-benzodioxane (IVb), which was condensed with isopropylamine, forming 6-(α-isopropylaminoacetyl)- 1,4-benzodioxane (IVc). The latter compound afforded the desired aminoethanol (III) upon reduction with potassium borohydride.Pharmacological examinations revealed that III was more potent in adrenergic beta-blocking effect, but was less toxic in comparison with pronethalol. |
| |
| Keywords: | |
|
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
