| 盐酸伊托必利漂浮片在家犬体内的药物动力学 |
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| 引用本文： | 金岩,于春艳,袁汀,李嫄. 盐酸伊托必利漂浮片在家犬体内的药物动力学[J]. 华西药学杂志, 2008, 23(6) |
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| 作者姓名： | 金岩 于春艳 袁汀 李嫄 |
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| 作者单位： | 中国医科大学附属盛京医院药剂科,辽宁,沈阳,110004;辽宁可济药业有限公司,辽宁,沈阳,110102 |
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| 摘 要： | 目的 研究自制盐酸伊托必利漂浮片在犬体内的药物动力学.方法 6只犬分别单剂景服用100 mg自制盐酸伊托必利漂浮片和市售盐酸伊托必利分散片,1周后两组交叉给药;采用HPLC法测定犬给药后不同时间的血药浓度.结果 盐酸伊托必利漂浮片、分散片的Tmax分别为6.62±1.05、1.94±0.31 h;Cmax分别为0.512±0.056、0.798 ±0.079 μg·ml-1;漂浮片的相对生物利用度是分散片的91.7%.结论 盐酸伊托必利漂浮片具有明显的缓释特征.
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| 关 键 词： | 盐酸伊托必利 漂浮片 药物动力学 牛物利用度 |
Pharmacokinetics of itopride hydrochloride floating tablet in dog |
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| JIN Yan,YU Chun-yan,YUAN Ting,LI Yuan. Pharmacokinetics of itopride hydrochloride floating tablet in dog[J]. West China Journal of Pharmaceutical Sciences, 2008, 23(6) |
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| Authors: | JIN Yan YU Chun-yan YUAN Ting LI Yuan |
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| Affiliation: | JIN Yan1,YU Chun-yan2,YUAN Ting1,LI Yuan1(1.Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China,2.Liaoning Keji Pharmaceutical Co.Ltd.,Shenyang 110102,China) |
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| Abstract: | OBJECTIVE To assess the relative bioavailability and bioequivalence of itopride hydrochloride floating tablet in dog.METHODS Six dogs were orally administered with a single dose of itopride hydrochloride floating tablet (test) or Itopride hydrochloride dispersible tablet (reference).The crossover dosing of 100 mg was taken in one week after the first single dose.The blood samples of the dogs were collected to measure the blood-drug concentration by HPLC with phenacetin as internal standard.The pharmacokinet... |
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| Keywords: | Itopride hydrochloride Floating tablet Pharmacokinetics Bioavailability |
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