| 水通道蛋白-5在人鼻息肉组织中的表达 |
| |
| 引用本文： | 李志海,高起学. 水通道蛋白-5在人鼻息肉组织中的表达[J]. 临床耳鼻咽喉头颈外科杂志, 2005, 19(4): 162-164 |
| |
| 作者姓名： | 李志海 高起学 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院耳鼻咽喉科,武汉,430030;华中科技大学同济医学院附属同济医院耳鼻咽喉科,武汉,430030 |
| |
| 摘 要： | 目的：探讨水通道蛋白-5(aquaporin-5，AQP-5)在维护正常鼻生理功能及在鼻息肉发病机制中的作用；明确AQP-5在下鼻甲和鼻息肉组织中不同部位的表达及分布。方法：取30例鼻息肉组织和12例下鼻甲组织，用4%多聚甲醛固定，石蜡包埋，连贯切片，应用免疫组织化学技术检测AQP-5在下鼻甲黏膜组织和鼻息肉组织中的阳性细胞的表达及分布。结果：下鼻甲AQP-5的黏膜固有层腺体的阳性细胞表达显著高于鼻息肉组织；而鼻息肉组织AQP-5的血管内皮的阳性细胞表达则显著高于下鼻甲黏膜组织。结论：AQP-5在鼻息肉组织固有层毛细血管及血窦内皮细胞呈过度表达，在腺体表达减少，AQP-5在病理状态下对鼻息肉的形成有一定作用。
|
| 关 键 词： | 水孔蛋白类 鼻息肉 免疫组织化学 |
| 文章编号： | 1001-1781(2005)04-0162-03 |
| 修稿时间： | 2004-01-28 |
Expression and distribution of aquaporin-5 in human nasal polyps |
| |
| LI Zhihai,GAO Qixue. Expression and distribution of aquaporin-5 in human nasal polyps[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2005, 19(4): 162-164 |
| |
| Authors: | LI Zhihai GAO Qixue |
| |
| Affiliation: | Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Lioohai@163.com |
| |
| Abstract: | Objective:To investigate the distribution and expression of aquaporin-5(AQP-5) in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps and the normal function of AQP-5 in the inferior turbinate.Method:AQP-5 were studied in 30 samples nasal polyps and 12 samples of inferior turbinates with immunochemistric staing.Result:The level of AQP-5 positive cells in the serous cells from nasal polyps were lesser than that from inferior turbinate,and the level of AQP-5 positive cells in the blood vessel endothelium from nasal polyps were more than that from inferior turbinate.Conclusion:AQP-5 may play the role in both the formation of nasal polyps and the function of normal nasal mucous membrane. |
| |
| Keywords: | Aquaporins Nasal polyps Immunochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
