| 大肠癌中C—erbB—2基因扩增的研究 |
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| 引用本文： | 骆成玉,祝学光.大肠癌中C—erbB—2基因扩增的研究[J].中国现代医学杂志,1999,9(5):4-7. |
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| 作者姓名： | 骆成玉 祝学光 |
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| 作者单位： | [1]北京军区总医院普外科 [2]北京医科大学人民医院 |
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| 摘 要： | 应用差异ＰＣＲ技术研究了大肠癌中Ｃ－ｅｒｂＢ－２基因的扩增情况。结果发现，大肠癌组织中Ｃ－ｅｒｂＢ－２基因存在明显扩增，该基因的扩增与大肠癌组织学分级、远处转移之间均有非常显著的关联。大肠癌中随着癌组织学分级程度的加重，Ｃ－ｅｒｂＢ－２基因扩增逐渐向高、低拷贝转移，说明，Ｃ－ｅｒｂＢ－２基因扩增在一定程度上反映着大肠癌分化状态和生物学行为，可作为大肠癌患者预后的重要参数，并可指导临床治疗。
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| 关 键 词： | 大肠肿瘤 C－erbB－2基因 基因扩增 |
THE STUDY OF THE AMPLIFICATION OF C-erbB-2 GENE IN COLORECTAL CARCINOMA |
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| Luo Chengyu,Zhu Xueguang,Li Shiyong,Wang Shenwu.THE STUDY OF THE AMPLIFICATION OF C-erbB-2 GENE IN COLORECTAL CARCINOMA[J].China Journal of Modern Medicine,1999,9(5):4-7. |
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| Authors: | Luo Chengyu Zhu Xueguang Li Shiyong Wang Shenwu |
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| Institution: | Luo Chengyu,Zhu Xueguang,Li Shiyong,Wang Shenwu. Beijing Army General Hospital,Beijing 100700,P.R.China |
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| Abstract: | The amplification of c-erbB-2 gene in colorectal carcinoma was studied by differential PCR technique. The results showed that the poorer the histologic was, the lower and /or higher copy of the c-erbB-2 gene amplification was transferred. The amplification was significantly higher in the patients with distant metastasis transfer than that in no-distant metastasis transfer. It suggested that the amplification of c-erbB-2 gene reflects the differentiation state and biological behavior of colorectal carcinoma to some extent. |
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| Keywords: | Colorectal carcinoma c-erbB-2 gene |
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