Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution |
| |
Authors: | Francesca Collina Anna De Chiara Amalia De Renzo Gaetano De Rosa Gerardo Botti Renato Franco |
| |
Affiliation: | 1. Pathology Unit, National Cancer Institute ??Giovanni Pascale??, Naples, Italy 2. Hematology Institute, ??Federico II?? University, Naples, Italy 3. Biomorphological and Functional Sciences Department, ??Federico II?? University, Naples, Italy 4. Pathology Unit, National Cancer Institute ??Giovanni Pascale??, Via Mariano Semmola, 80131, Naples, Italy
|
| |
Abstract: | Ocular adnexa MALT-lymphomas represent approximatively 5-15% of all extranodal lymphomas. Almost 75% of OAMLs are localized in orbital fat, while 25% of cases involves conjunctive. MALT-lymphomas often recognize specific environmental factors responsible of lymphoma development and progression. In particular as Helicobacter pylori in gastric MALT lymphomas, other bacterial infections have been recognized related to MALT lymphomas in specific site. Recently Chlamydia psittaci has been identified in Ocular Adnexa MALT lymphomas, with variable frequence dependently from geographic areas. Thus bacterial infection is responsible of clonal selection on induced MALT with subsequent lymphoma development. Moreover Chlamydia psittaci could promote chromosomal aberration either through genetic instability as a consequence of induced proliferation and probably through DNA oxidative damage. The most common translocation described in MALT lymphomas affects NF-kB pathway with a substantial antiapoptotic effect. Several therapeutic approaches are now available, but the use of antibiotic-therapy in specific cases, although with conflicting results, could improve the treatment of ocular adnexa MALT lymphomas. In this review we analyse the most relevant features of Ocular adnexa MALT lymphomas, underlining specific biological characteristics mainly related to the potential role of Chlamydia psittaci in lymphomagenesis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|