厦门地区女性人乳头瘤病毒感染状况调查

目的 对厦门地区妇女宫颈人类乳头瘤病毒（human papilloma virus,HPV）亚型进行筛查,以探讨其分布规律.方法 采用凯普医用核酸分子快速杂交仪,对7683名2013年1月-2013年12月到厦门市174医院妇科门诊或病房就诊的女性进行生殖道21种HPV感染基因亚型筛查.结果 7683例样本中,HPV感染者1421例,阳性率18.50％.感染人群主要集中在30～39岁.其中高危型HPV阳性率为16.01％,低危型HPV阳性率为2.49％.单一基因型别者1148例,阳性率为14.94％;双重感染者220例阳性率为2.86％;三重以上感染者53例,阳性率为0.70％;HPV感染阳性率居前6位的基因型分别为HPV-52（3.64％）、HPV-16 （3.33％）、HPV-58（2.98％）、HPV-53（2.16％）、HPV-CP8304（1.91％）和HPV-18（1.09％）.结论 厦门地区妇女HPV感染率高,且以高危型单一基因亚型感染为主;感染基因型别主要以HPV-52、16、58、53、CP8304和18为主,具有一定的地域差异性;52及58型感染率高,对于疫苗的研制和开发有参考意义.

HPV prevalence and type distribution of women in Xiamen city

Objective Cervical cancer is a major public health problem worldwide.Human papillomavirus （HPV） infection plays an important role in the development of cervical cancer,but the prevalence of HPV infection in women of Xiamen city has not been evaluated.We report the first data on HPV prevalence and type distribution in Southeast China.Methods HPV prevalence and genotype distribution were investigated in 7683 consecutively women with or without cervical lesions in Southeast China.The subtypes of 21 kinds of HPV infected gene were examined by using cape rapid acid hybridization medical instrument.Results In our study group,18.50% （1421/7683） of the patients were positive for HPV including high-risk HPV infected rate 16.01% and low-risk HPV infected rate 2.49%.In addition,the highest HPV prevalence was found in age group 30-39 years old.1148 cases were single gene type with the detection rate 14.94%.While 220 cases were double infected with the detection rate 2.86%.53 cases were triple and over triple with the detection rate 0.70%.Most frequent types were 52 （3.64%）,16 （3.33%）,58 （2.98%）,53 （2.16%）,CP8304 （1.91%） and 18 （1.09%）,respectively.Conclusions Infection with high risk types of HPV is common in Xiamen City.Enhanced and systematic screening for cervical cancer is needed.Our results call for the implementation of a national HPV vaccine program in China.The infected genes mainly are HPV-52,16,58,53,CP8304 and 18.The HPV-52 and 58 type infected rates are high which provides reference value for development of the vaccine.