静息态功能磁共振成像技术对右侧小脑参与语言功能的应用研究

目的 通过静息态功能磁共振成像技术来探讨小脑在产生语言中的作用机制。 方法 运用西门子3.0T磁共振仪获得静息态数据，用DPARSF软件对静息态数据进行预处理。首先对12例卒中后失语患者和20例正常对照者进行低频振荡振幅（ALFF）分析，在REST软件中行两样本t检验，得到失语组右侧小脑的某一脑区ALFF信号低于正常对照组，然后把此脑区作为种子点和ROI选取区，在正常对照组中进行单样本t检验，得到功能连接图。 结果 与正常对照组相比，失语组左侧颞中回、左侧前额叶内侧回、右侧小脑的ALFF减低；右侧小脑在正常对照组功能连接的脑区有小脑蚓部、左侧颞中回、左侧额上回内侧面、辅助运动区。 结论 右侧小脑本身及通过影响与其存在功能连接和解剖连接的脑区参与语言的产生。

Analysis of the mechanism of right cerebellum in language using resting state functional magnetic resonance imaging

Objective To elucidate the generation mechanism of cerebellum in language by resting state functional magnetic resonance imaging （fMRI）.Methods Siemens verio 3.0T MR Scanner was used to obtain all of the subjects of fMRI data.The fMRI data were processed with the software of Data Processing Assistant for Resting-State fMRI Analysis Toolkit.Firstly,12 patients with poststroke aphasia and 20 normal controls were analyzed by amplitude of low frequency fluctuation （ALFF） and performed with two sample t-test by REST software; Secondly,decreased ALFF of certain brain regions of the cerebellum were selected as the regions of seed point and ROI,and then calculated the single sample t-test in normal controls to obtain function connectivity map.Results As compared with those in normal subjects,the regions showing decreased ALFF in aphasia patients were distributed in left middle temporal gyrus,left medial prefrontal gyrus,fight cerebellum.Positive functional connectivity with certain brain regions of the cerebellum ROI was seen in cerebellum tonsil,left middle temporal gyrus,left medial superior frontal gyrus and supplementary motor area.Conclusion Right cerebellum itself and through its impact on the presence of functional connections and structural connections of the brains participate in language production.