HPV16 E5蛋白在宫颈癌发生中的作用

人乳头瘤病毒16型（HPV16）与宫颈癌密切相关，编码E5蛋白。HPV16 E5蛋白是一种细胞膜整合蛋白，主要分布于高尔基体和内质网。大量研究证明，HPV16 E5蛋白通过影响表皮生长因子受体信号转导途径及环氧化酶2（COX-2）途径的活性，增加宿主细胞的免疫逃避，调节细胞周期，促进细胞转化、增殖，减少细胞凋亡，促进肿瘤中新生血管的形成等机制影响宫颈癌的发生与发展。就HPV16 E5蛋白的分子生物学特点及与宫颈癌细胞增殖侵袭凋亡关系的研究进展进行综述。

Current Study on HPV16 E5 Protein in Cervical Cancer

HPV16 virus is the most correlative HPV type to cervical cancer and Encoding E5 protein. HPV16 E5 protein as one of membrane integration of proteins，mainly distributed in the golgi apparatus and endoplasmic reticulum. Numerous studies have demonstrated that HPV16 E5 protein regulates cervical cancer cell proliferation and invasion by promoting the activity of the epidermal growth factor receptor signal transduction pathway and COX -2 pathway，increasing the host cell immune evasion ,regulating the cell cycle，promoting cell transformation and reducing cell apoptosis. This paper summarized the research progress of the relationship between the HPV16 E5 protein of molecular biology and invasion of cervical cancer proliferation.