粥样硬化易损斑块传统影像与分子影像检测与评价现状

易损斑块引发的心脑血管急性事件是威胁人类生命健康的主要原因之一,检测与评价斑块的易损性尤为重要.传统影像学技术多从形态结构方面评价粥样斑块,目前的扫描技术有一定进步,但在早期发现和评估斑块方面有其局限性.分子影像学方法在核素显像、MRI、超声和光学成像中均有应用,对易损斑块的显像靶点涉及斑块组成、炎症、血栓形成、新生血管、凋亡等方面,能反映斑块形态结构和功能代谢的改变.多模式分子影像综合了各单一显像模式的优势,将会为易损斑块的早期检测与评估提供帮助.该文就传统影像与分子影像在粥样硬化易损斑块检测与评价中的现状进行综述.

Current situation of detection and evaluation for atherosclerosis vulnerable plaque by conventional imaging and molecular imaging

Cardiovascular and cerebrovascular emergency events caused by vulnerable plaque are one of the major threats to human health,so it＇s very important to detect and evaluate vulnerable property of plaque.Conventional imaging evaluates plaque by morphology.Although lots of progress has been made in technology,limitation still exists in early detection and evaluation.Molecular imaging has been applied in radionuclide imaging,MRI,ultrasound and optical imaging.Imaging targets of vulnerable plaque include plaque composition,inflammation,thrombosis,angiogenesis and apoptosis etc,which represent the morphology and functional metabolism of plaque.Multimodal molecular imaging combines advantages of each single imaging method,providing help for early detection and evaluation of vulnerable plaque.This article makes a review about current situation of detection and evaluation for atherosclerosis vulnerable plaque by conventional imaging and molecular imaging.