贵州省苗族、布依族及汉族 EB病毒感染情况及鼻咽癌诊断试验效果评价研究 |
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引用本文: | 胡德峰,令狐颖,苗燕,梁隆俐,钟宇,鲍安珍. 贵州省苗族、布依族及汉族 EB病毒感染情况及鼻咽癌诊断试验效果评价研究[J]. 贵州医药, 2014, 0(4): 304-307 |
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作者姓名: | 胡德峰 令狐颖 苗燕 梁隆俐 钟宇 鲍安珍 |
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作者单位: | 胡德峰 (贵州省人民医院体检中心,贵州贵阳,550002); 令狐颖 (贵州省人民医院体检中心,贵州贵阳,550002); 苗燕 (贵州省人民医院体检中心,贵州贵阳,550002); 梁隆俐 (贵州省人民医院体检中心,贵州贵阳,550002); 钟宇 (贵州省人民医院体检中心,贵州贵阳,550002); 鲍安珍 (贵州省人民医院体检中心,贵州贵阳,550002); |
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基金项目: | 本课题受贵州省科技厅基金资助(项目编号:黔科合SY,字(2011)007号) |
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摘 要: | 目的调查贵州省苗族、布依族及汉族EB病毒感染情况并探讨EB病毒特异性Zta-IgA、EBNA1-IgA与VCA-IgA抗体定量检测对鼻咽癌的诊断价值。方法采用随机抽样的方法抽取苗族、布依族及汉族共3040例研究对象,收集研究对象的基本信息;采用ELISA法检测研究对象血浆EB病毒的Zta-IgA、EBNA1-IgA、VCA-IgA标志物水平,分析上述指标诊断鼻咽癌的价值。结果3040例研究对象中,Zta-IgA阳性率为15.03%;EBNA1-IgA阳性率为16.09%;VCA-IgA阳性率为14.41%(χ2=16.027,P=0.000);Zta=IgA、EBNAI-IgA、VCA-IgA阳性率均为布依族最高(Pd0.05);〉45岁组Zta-IgA、EBNA1-IgA、VCA-IgA阳性率均明显高于≤45岁年龄组(P〈0.05);吸烟、饮酒可以明显提高Zta-IgA、EBNA1-IgA、VCA-IgA阳性率(P〈0.05);三者联合检测对诊断鼻咽癌的灵敏度和特异度均明显升高。结论贵州省少数民族EB感染率水平较高,应开展Zta-IgA、EB-NA1-IgA、VCA-IgA监测;三者联合检测对鼻咽癌的早监测、早发现有积极意义。
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关 键 词: | 鼻咽癌 EB病毒 少数民族 诊断试验 |
The investigation of EB virus infection of Miao,Buyi and Han population and evaluation of the diagnosis of Zta-IgA,EBNA1-IgA and VCA-IgA antibody for nasopharyngeal carcinoma in Guizhou |
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Affiliation: | Hu Defeng, Ning Huying, Miao Yan, Liang Longli.( Department of Medical Examination Center, Guizhou Provincial People's Hospital, Guiyang 550002, China.) |
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Abstract: | Objective To investigate EB virus infection of Miao, Buyi and Han population and evaluate the diagnosis of Zta-IgA, EBNAI-IgA and VCA-IgA antibody for nasopharyngeal carcinoma in Guizhou Province. Methods A random sampling method was used to select 3040 subjects from Miao, Buyi and Han, collecting basic information. ELISA was used to detected serum Zta-IgA, EBNA1- IgA, VCA-IgA of EB virus for analysing the value of these indicators diagnosis of NPC. Results Zta- IgA positive rate was 15.03%. EBNAI-IgA -positive rate was 16.09%. VCAI-IgA -positive rate was 14.41~ (X2 ----- 16. 027, P~ 0. 000). Zta-IgA, EBNAI-IgA , VCA-IgA-positive rate of Buyi wasthe highest (P~0.05). Zta-IgA, EBNAI-IgA, VCA-IgA -positive rate of ~ 45 age group was signifi- cantly higher than that of ~ 45 age group (P〈0.05). Smoking, alcohol could significantly increase Zta-IgA, EBNAI-IgA, VCA-IgA -positive rate (P〈0.05). Combined detection of Zta-IgA, EBNA1- IgA, VCA-IgA could significantly increase the sensitivity and specificity for diagnosis of NPC. Conclu- sion EB prevalence of minority in Guizhou is high and Zta-IgA, EBNAI-IgA, VCA-IgA monitoring should be carried out; There is positive significance of combined detection of three to the early monitoring, early detection of nasopharyngeal carcinoma. |
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Keywords: | Nasopharyngeal carcinoma EB virus Minorities Diagnostic tests |
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