高精度持续循环腹腔热灌注化疗联合静脉化疗治疗卵巢癌的临床研究

目的：观察高精度持续循环腹腔热灌注化疗（IPHC）联合静脉化疗治疗卵巢癌的临床疗效。方法：分析2011—2012年就诊于郑州大学人民医院50例行满意的卵巢癌减灭术患者，随机分为2组。灌注组28例，行高精度持续循环IPHC联合静脉化疗；对照组22例，行“紫杉醇脂质体135 mg/m2+奥沙利铂135 mg/m2”方案（PT方案）静脉化疗，观察2组患者的临床治疗效果。结果：2组患者术后1个月、3个月血清CA125降至正常比例比较差异有统计学意义（均P＜0.05）。2组患者术后1个月、3个月腹水治疗有效率比较差异有统计学意义（均P＜0.05）。需要对症处理的化疗后Ⅱ级毒副反应灌注组低于对照组（χ2=7.417，P=0.006）。生活质量改善率灌注组高于对照组（χ2=5.936，P=0.015）。结论：高精度持续循环IPHC联合静脉化疗能够提高卵巢癌的临床疗效，有效地控制卵巢癌恶性腹水，降低严重的化疗毒副反应的发生率，改善生活质量。

The Research of Ovarian Cancer with High Accuracy Continuous Circulation Intraperitoneal Hyperthermic Chemotherapy and Intravenous Chemotherapy

Objective：Observe the clinical efficacy of the high accuracy continuous circulation intraperitoneal hyperthermic chemotherapy （IPHC） and intravenous chemotherapy for ovarian cancer. Methods：50 patients of The People′s Hospital of Zhengzhou University with satisfied ovarian cancer reductive surgery were divided into two groups：IPHC group, 28 patients with high accuracy continuous circulation intraperitoneal hyperthermic chemotherapy and intravenous chemotherapy;Control group, 22 patients with ″paclitaxel liposome 135 mg/m2 + oxaliplatin 135 mg/m2 ″（PT） intravenous chemotherapy，observed clinical treatment effect of two groups patients. Results：Compared the percentage of nomal CA125 of two groups patients after 1 month, 3 months, the difference was statistically significant （all P＜0.05）. Two group patients one month, three months ascites treatment efficiency difference was statistically significant（P＜0.05）. Compared the grade Ⅱ side effect of chemotherapy，IPHC group was lower than control group （χ2=7.417，P=0.006）；and IPHC group′s improment rate of life quality was higher than control group′s （χ2=5.936，P=0.015）. Conclusions：High accuracy continuous circulation intraperitoneal hyperthermic chemotherapy and intravenous chemotherapy can improve the clinical efficacy of ovarian cancer，control of malignant ascites of ovarian cancer patients effectively，reduce side effects of chemotherapy and improve quality of life.