|
|||||
|
|
| 中心减压植骨联合骨髓间充质干细胞移植治疗股骨头缺血坏死 | |
| 引用本文： | 孙薏,张文华,姚一民,邵文军,岳伦丽,张朵,陈健.中心减压植骨联合骨髓间充质干细胞移植治疗股骨头缺血坏死[J].西南国防医药,2008,18(6). |
| 作者姓名： | 孙薏 张文华 姚一民 邵文军 岳伦丽 张朵 陈健 |
| 作者单位： | 1. 解放军第452医院,肿瘤血液中心,四川,成都,610021 2. 解放军第452医院,放射介入中心,四川,成都,610021 3. 解放军第452医院,骨科,四川,成都,610021 |
| 基金项目： | 四川省卫生厅资助项目 |
| 摘 要： | 目的：观察中心减压植骨联合骨髓问充质干细胞移植治疗股骨头缺血坏死临床疗效。方法：根据ARCO的骨坏死分期标准，选取I～Ⅱ期病人28例，其中进行中心减压植骨联合干细胞移植的治疗组15例，单纯中心减压植骨的对照组13例。治疗组经过骨髓间充质干细胞采集及分离、中心减压注人造血干细胞以及松质骨植入几步完成，而对照组仅进行中心减压。结果：在术后18个月随访中，治疗组髋关节疼痛指数比对照组明显降低（P〈0．001）；对患侧髋关节行磁共振检查和Harris评分，治疗组评分从55．91±9．70上升为81．98±10．95，而对照组从56．75±7．65上升到67．14±10．95，两组比较治疗效果有统计学差异（P〈O．01）。结论：中心减压植骨联合骨髓间充质干细胞移植治疗早期股骨头缺血坏死安全、有效，但还需要进行大样本及长期随访进一步验证。 |
| 关 键 词： | 股骨头坏死 减压植骨 问充质干细胞移植 |
Treatment of osteonecrosis of femoral head by combination of center decompression and implantation of autogenous bone and mesenchymal stem cells |
|
| SUN Yi,ZHANG Wen-hua,YAO Yi-min,SHAO Wen-jun,YUE Lun-li,ZHANG Duo,CHEN Jian.Treatment of osteonecrosis of femoral head by combination of center decompression and implantation of autogenous bone and mesenchymal stem cells[J].Medical Journal of National Defending forces in Southwest China,2008,18(6). | |
| Authors: | SUN Yi ZHANG Wen-hua YAO Yi-min SHAO Wen-jun YUE Lun-li ZHANG Duo CHEN Jian |
| Institution: | SUN Yi1,ZHANG Wen-hua2,YAO Yi-min3,SHAO Wen-Jun1,YUE Lun-li1,ZHANG Duo1,CHEN Jian1 Hospital 452 of PLA: 1.Department of Oncology , Hematology,2.Department of Radioactivity Intervention,3.Department of Orthopedics,Chengdu,610021,China. |
| Abstract: | Objective:To observe the therapeutic effects of combination of center decompression and implantation of autogenous bone plus mesenchymal stem cells(MSCs) on femoral head osteonecrosis.Methods:28 patients(32 hips) with stage-I or II osteonecrosis of the femoral head according to the system of the ARCO were enrolled in this trial.15 patients(bone-marrow-graft group) were performed center decompression plus implantation of autologous bone-marrow mononuclear cells and other 13 patients were only performed cente... |
| Keywords: | femoral head osteonecrosis center decompression mesenchymal stem cells transplantation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |