| 非小细胞肺癌的DNA表达谱(英文) |
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| 引用本文： | 区兆基,曹志成,邹尚俊,杨梦苏. 非小细胞肺癌的DNA表达谱(英文)[J]. 中国肺癌杂志, 2009, 12(1). DOI: 10.3779/j.issn.1009-3419.2009.01.002 |
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| 作者姓名： | 区兆基 曹志成 邹尚俊 杨梦苏 |
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| 作者单位： | Department;Clinical;Oncology;Queen;Elizabeth;Hospital;Hong;Kong;Biology;Chemistry;City;University; |
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| 摘 要： | 作为新一代基因诊断技术,DNA芯片已广泛应用于肺癌分子分类、基因表达和分子通路的病理变异分析、预后及转移监测、个体化治疗和药物开发等.基于技术差异、不同患者人群和生物多样性等因素,目前DNA芯片发展的主要障碍为缺乏机械性、可靠性和可重复性.冀望借着更好的标准化和分析手段,利用高维数据分析方法来减少噪音,未来DNA芯片技术或能实际应用于肺癌的个体化诊疗.
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| 关 键 词： | 基因芯片 DNA表达谱 肺癌 生物标志 表皮生长因子受体突变 吸烟 个体化诊疗 |
DNA Expression Profiles of Non-Small Cell Lung Cancer |
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| Joseph Siu-Kie AU,William Chi-Shing CHO,Sheung-Chun CHOW,Mengsu YANG. DNA Expression Profiles of Non-Small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2009, 12(1). DOI: 10.3779/j.issn.1009-3419.2009.01.002 |
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| Authors: | Joseph Siu-Kie AU William Chi-Shing CHO Sheung-Chun CHOW Mengsu YANG |
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| Abstract: | DNA expression profiling using microarray technology has been applied to studies on the molecular classification of lung cancers, pathogenetic alterations in gene expressions and cellular pathways, prediction of prognosis and metastasis, customized therapies, and drug development.Due to the wide variation in technical factors, different cohorts of patients and biological heterogeneity, the major hurdle to successful clinical application is lack of robustness, reliability and reproducibility of data.With bet... |
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| Keywords: | Microarray DNA expression profiling Lung neoplasms Biomarkers Epidermal growth fac-tor receptor(EGFR) mutation Smoking Personalized medicine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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