| 柴芍安神解郁颗粒质量标准研究 |
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| 引用本文： | 李丽娟,彭丽诗,李素梅,罗文汇.柴芍安神解郁颗粒质量标准研究[J].湖南中医杂志,2014(6):151-153. |
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| 作者姓名： | 李丽娟 彭丽诗 李素梅 罗文汇 |
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| 作者单位： | [1]广东省第二中医院（广东省中医药工程技术研究院）,广东广州510095 [2]广州中医药大学,广东广州510405 |
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| 基金项目： | 基金项目：广东省中医药局资助项目（编号：20131110） |
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| 摘 要： | 目的：建立柴芍安神解郁颗粒的质量控制标准。方法：采用薄层色谱法对制剂中的丹参、柴胡、石菖蒲3味药进行定性鉴别；采用高效液相色谱法对制剂中的丹酚酸B进行定量测定。结果：薄层色谱法可清晰鉴别丹参、柴胡和石菖蒲，且阴性对照无干扰；丹酚酸B在0．0518～0．5180μg范围内线性关系良好，相关系数r=0．9999，平均回收率为98．82％．RSD=1．27％。结论：本方法操作简单、专属性强、重现性好、数据准确，可用于疏肝安神的质量控制。
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| 关 键 词： | 柴芍安神解郁颗粒 薄层色谱法 高效液相色谱法 丹酚酸B 质量标准 |
Study on quality standard for Chaishao Anshen Jieyu granules |
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| Institution: | LI Li -juan ,PENG Li - shi ,LI Su - mei ,LUO Wen - hui ( 1. Guangdong Second Provincial Traditional Chinese Medicine Hospital( Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology), Guangzhou 510095, Guangdong, China ; 2. Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China) |
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| Abstract: | Objective ：To establish the quality control standard for Chaishao Anshen Jieyu granules. Methods：Thin- layer chroma- tography（TLC） was used to identify Salvia mihiorrhiza, Bupleurum chinense, and Rhizoma Acori graminei in Chaishao Anshen Jieyu granules. High - performance liquid chromatography was used to determine the content of salvianolic acid B. Results ： Salvia miltiorrhiza, Bupleurum chinense, and Rhizoma Acori graminei were well identified by TLC, and the negative control had no interference. Salvianolic acid B showed a good linear relationship within O. 0518 -0. 5180 μg（ r = 0. 9999）. The average recovery rate was 98.82% , with a relative standard deviation of 1.27%. Conclusion：This method has the advantages of easy operation, high specificity, high repeatability, and high accuracy and can be used for the quality control of Chaishao Anshen Jieyu granules. |
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| Keywords: | thin - layer chromatography high - performance liquid chromatography Chaishao Anshen Jieyu granules salvianolic acid B content determination |
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