| HPLC法测定复方丙谷胺片含量 |
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| 引用本文： | 王斌,易必新,李昌亮. HPLC法测定复方丙谷胺片含量[J]. 中国药师, 2014, 0(11): 1967-1969 |
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| 作者姓名： | 王斌 易必新 李昌亮 |
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| 作者单位： | 湖南省食品药品检验研究院 长沙 410001;湖南省食品药品检验研究院;湖南省食品药品检验研究院 |
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| 摘 要： | 目的：拟建立用高效液相色谱法测定复方丙谷胺片中丙谷胺含量的方法。方法：采用Diamonsil C18色谱柱（250 mm×4.6 mm,5μm）,以2%醋酸铵-甲醇（40∶60）为流动相,检测波长为225 nm,外标法计算含量。结果：丙谷胺在2.60-208.10μg与峰面积有良好的线性关系,r=0.999 9,平均加样回收率为99.8%,RSD为0.5%（n=6）。结论：HPLC法测定复方丙谷胺片中丙谷胺含量准确度高,操作简单,重复性好。
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| 关 键 词： | 高效液相色谱法 定氮法 丙谷胺 |
| 收稿时间： | 2014-05-04 |
| 修稿时间： | 2014-07-09 |
Determination of Compound Proglumide Tablets by HPLC |
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| Wang Bin,Yi Bixin and Li Changliang. Determination of Compound Proglumide Tablets by HPLC[J]. China Pharmacist, 2014, 0(11): 1967-1969 |
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| Authors: | Wang Bin Yi Bixin Li Changliang |
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| Affiliation: | Hunan Institute for Food and Drug Control, Changsha 410001, China;Hunan Institute for Food and Drug Control;Hunan Institute for Food and Drug Control |
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| Abstract: | Objective：To establish an HPLC method for the determination of compound proglumide tablets. Methods：A Diamonsil C18（250 mm ×4.6 mm,5 μm）column was used. The mobile phase was 2% ammonium acetate-methanol （40∶60）, the detection wavelength was 225nm, and an external standard method was employed. Results：The linear range of proglumide was 2. 60-208. 10 μg （r=0. 999 9）, and the average recovery was 99. 8%（n=6,RSD=0. 6%）. Conclusion： The HPLC determination method for compound proglumide tablets is accurate, simple and reproducible. |
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| Keywords: | HPLC Nitrogen determination method Proglumide |
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