长期萘接触对人体的危害及中毒诊断指标研究

通过职业流行病学调查和临床动态观察，发现长期萘接触工人的白细胞、血小板减少及眼晶状体混浊检出率均与对照组呈极显著性差异（Ｐ＜０．００１）。萘接触工人血清ＳＯＤ同功酶、ＧＳＨ－ＰＸ活性显著低于对照组，而ＬＰＯ水平明显高于对照组，与对照组呈极显著性差异（Ｐ＜０．００１）。初步认为白细胞、血小板减少及眼晶体混浊可做为慢性萘中毒的客观诊断指标。而ＬＰＯ、ＳＯＤ同功酶、ＧＳＨ－ＰＸ作为判断萘对人体危害的早期生物监测指标和中毒的辅助诊断指标，可进一步探讨。

Study on the hazards to human body of long-term exposure to naphthalene and the poisoning diagenostic index

The authors made an occupational epidemiological investigation and clinical observation. It was found that the decrease of white blood cells and platelets and the positive rate of lense opacity in the workers who were exposed to naphthalene for a long time were significantly different from those of the controls (P<0.00).The serum superoxide dismutaseisoenzymes (SOD) and the glutathions peroxidases (GSH-PX) activity of the workers exposed to naphthalene were significantly lower than those of the control,whereas the level of lipoperoxides (LPO) was significantly higher than that of the control.There was extremely significant difference between the two (P<0.001).Therefore,it is thought that the decrease of white blood cells and platelets and lense opacity can be used as the objective diagnostic index of chronic naphthalene poisoning.