镍作业工人细胞免疫功能、血清硒和过氧化脂质含量的变化

９６名镍作业工人测定结果：非特异酯酶阳性细胞百分率（ＡＮＡＥ＋％）为７６．８％±８．０％，Ｔ细胞亚群ＣＤ２、ＣＤ４、ＣＤ８阳性细胞百分率（ＣＤ＋２％、ＣＤ＋４％、ＣＤ＋８％）及ＣＤ＋４／ＣＤ＋８比值分别为６５．６％±１０．５％、５６．３％±１２．１％、３４．３％±８．２％和１．７６±０．６；酵母多糖刺激的外周血多形核白细胞化学发光（ＰＭＮ－ＣＬ）本底和峰值分别为４８±２３和３０７３±６８４ＣＰＳ／１０６ＰＭＮ；血清硒和丙二醛含量分别为１．２２±０．２３和４．７６±０．８８μｍｏｌ／Ｌ。与非镍作业的地区对照组比较，Ｔ细胞ＣＤ＋８％增高，ＣＤ＋４／ＣＤ＋８比值下降，化学发光的本底值降低，峰值增加，血清Ｓｅ含量下降，丙二醛含量升高。分析镍作业工人工龄与后三项指标变化的关系，工龄大于２０年与小于１０年有统计学上明显差别。这些观察指标为镍作业人员医学观察增加新的监护指标提供依据。

Alterations of cell immunity,contents of selenium and lipid peroxidation in serum of workers exposed to nickel compounds

Contents of selenium and malondialdehyde (MDA) in serum and cell immunity were determined in 96 workers exposed to nickel compounds and compared with that of non-nickel exposed workers.The percentages of lymphocytes with positive staining for nonspecific esterase (ANAE+%)was 76.8%±8.0%.T-lymphocyteand its sub-populations CD+2,CD+4,CD+8%and ratios for CD+4/CD+ 8 were 65. 6±10.5,56. 3±12.3,34.3±8.2 and 1.76±0.6,respectively. The values for chemiluminescence (CL) background and peak of blood were 48±23 and 3073±684 cps/106 PMN.The contents of selenium and MDA were 1.22±0.23 and 4.76 ±0. 88μmol/L,respectively. Comparing with those data of non-nickel exposed workers,most of these indications showed significant alterations. It was also found that the alterations in CL of blood and contents of selenium and MDA in serum were more profound in workers who have been exposed to nickel compounds for more than 20 years.