Activation and Migration of Adventitial Fibroblasts Contributes to Vascular Remodeling |
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| Authors: | Aiming Wu Jie Wang Hong Chang Yizhou Zhao Yan Zhang Yingqiu Mao Lixia Lou Yonghong Gao Dongmei Zhang Tong Li Tao Yang Lei Wang Cuiling Feng Mingjing Zhao |
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| Affiliation: | 1. Beijing University of Chinese Medicine, Dongzhimen Hospital, Key Laboratory of Chinese Internal Medicine, Ministry of Education & Beijing, Beijing 100700, China;2. Beijing University of Chinese Medicine, Dongzhimen Hospital, Laboratory for Integrated Traditional Chinese and Western Medical Research of Qi‐Blood, Beijing 100700, China;3. Huayuanlu Community Health Service Center, Beijing 100088, China;4. Department of Ultrapathology of the Neurosurgical Institute Affiliated Bayi Brain Hospital, Army General Hospital of PLA, Beijing 100700, China;5. Beijing University of Chinese Medicine, Beijing 100029, China;6. Peking University People's Hospital, Beijing, China |
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| Abstract: | The rat carotid artery balloon injury model was used to prove the activation and migration of adventitial fibroblasts. We found that at day 7 after injury, adventitial fibroblasts proliferated, transformed into myofibroblasts under transmission electron microscopy in the model group. Simultaneously, we proved that the adventitial cells migrated to the media and intima on seventh day after injury by directly labeled the adventitial cells by the in vivo gene transfer technique. Moreover, we captured the precise moment when the adventitial fibroblasts migrated from the adventitia to the media through the external elastic plate under transmission electron microscope. This study provides direct evidences that adventitial fibroblasts activate and migrate to the media and intima, then actively take part in revascularization. Anat Rec, 301:1216–1223, 2018. © 2018 Wiley Periodicals, Inc. |
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| Keywords: | adventitial fibroblasts migration vascular remodeling |
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