Synthesis and biological evaluation of phloroglucinol derivatives possessing α‐glycosidase,acetylcholinesterase, butyrylcholinesterase,carbonic anhydrase inhibitory activity |
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| Authors: | Serdar Burmaoglu Ali O. Yilmaz Parham Taslimi Oztekin Algul Deryanur Kilic Ilhami Gulcin |
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| Affiliation: | 1. Faculty of Science, Department of Chemistry, Ataturk University, Erzurum, Turkey;2. Tercan Vocational High School, Erzincan University, Erzincan, Turkey;3. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Mersin University, Mersin, Turkey;4. Faculty of Art and Science, Department of Chemistry, Aksaray University, Aksaray, Turkey |
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| Abstract: | A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including α‐glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed Ki values of 1.14–3.92 nM against AChE, 0.24–1.64 nM against BChE, 6.73–51.10 nM against α‐glycosidase, 1.80–5.10 nM against hCA I, and 1.14–5.45 nM against hCA II. |
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| Keywords: | α ‐glycosidase acetylcholinesterase butyrylcholinesterase carbonic anhydrase phloroglucinol derivatives |
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