Design,synthesis, and evaluation of new α‐aminonitrile‐based benzimidazole biomolecules as potent antimicrobial and antitubercular agents |
| |
Authors: | Irfan N Shaikh Kallappa M Hosamani Mahantesh M Kurjogi |
| |
Institution: | 1. Department of Chemistry, SECAB Institute of Engineering and Technology, Vijayapur, India;2. P.G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, India;3. Department of Biotechnology and Microbiology, Karnatak University, Pavate Nagar, Dharwad, India |
| |
Abstract: | The study explores the one‐pot synthesis of novel α‐aminonitriles by reacting 4‐(1H‐benzimidazol‐2‐yl)methoxy]benzaldehyde, substituted anilines and sodium cyanide using a catalytic amount of copper dipyridine dichloride (CuPy2Cl2) and employing the Strecker reaction under mild conditions. All the synthesized compounds were screened for antimicrobial and antitubercular activity. The promising lead compounds 4d and 4e were identified, with MIC values ranging between 3.9 and 7.8 µg/mL against different bacterial strains. Compounds 4c–e and 4g also showed good antifungal activities against the tested fungal strain. Among those tested, compound 4e exhibited excellent antitubercular activity (MIC 0.05 μg/mL) with a low level of cytotoxicity, suggesting that compound 4e is a promising lead for subsequent investigations in search for new antitubercular agents. |
| |
Keywords: | α ‐aminonitriles antimicrobial antitubercular benzimidazoles one‐pot synthesis |
|
|