| 核磁共振测定蛋白质构象 |
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| 引用本文： | 姜厚理,杜泽涵.核磁共振测定蛋白质构象[J].军事医学科学院院刊,1993,17(2):152-156. |
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| 作者姓名： | 姜厚理 杜泽涵 |
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| 作者单位： | 军事医学科学院仪器测试中心
(姜厚理，冯锐)，军事医学科学院基础医学研究所(杜泽涵) |
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| 摘 要： | 核磁共振(NMR)已成为与X射线晶体衍射相补充的研究蛋白质构象的方法,而且其应用日益深入。本文综述了NMR测定蛋白质构象的基本原理、主要步骤、现状及前景,并对NMR的应用和成就与晶体衍射法进行了简要的比较讨论。
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| 关 键 词： | 蛋白 构象 NMR 成像 |
NMR investigation of protein conformation |
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| Jiang Houli,Feng Rui,Du Zehan Instrumental Analysis Centre,Academy of Military Medical Sciences Institute of Basic Medical Sciences,Academy of Military Medical Sciences.NMR investigation of protein conformation[J].Bulletin of the Academy of Military Medical Sciences,1993,17(2):152-156. |
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| Authors: | Jiang Houli Feng Rui Du Zehan Instrumental Analysis Centre Academy of Military Medical Sciences Institute of Basic Medical Sciences Academy of Military Medical Sciences |
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| Abstract: | Protein conformation is one of the foundations of protein design and protein engi-neering. Nuclear magnetic resonance (NMR) spectroscopy is widely used in protein structure de-termination, in addition to the X ray diffraction techniques for single protein crystal. NMR meth-od enables one to carry out detailed structural study of protein in solution and non crystalline pro-teins and promises new insight into the dynamics of protein molecules and protein foldingproblem. This review briefly describes the strategies, procedures, current situation and prospect ofthe new approach. |
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| Keywords: | NMR protein conformation |
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