高强度聚焦超声治疗H_(22)肝肿瘤的效果:不同治疗方案的评价

实验研究已证明高强度聚焦超声(HIFU)提供了一种局部切除肿瘤的体外治疗手段.本文选择不同方案的HIFU治疗H_(22)肝肿瘤.73只ICR H_(22)肿瘤荷鼠分对照组和HIFU治疗组.后者根据辐照时间和次数变化分不同治疗亚组.结果显示HIFU对各治疗组小鼠H_(22)肿瘤生长均有抑制作用.同一声强下,切除肿瘤的局部效果取决于辐照时间和次数.

Effects of High Intensity Focused UItrasound on H_(22) Liver Tumor :An Evaluation With Different Therapeutic Programs

In order to choose the optimal conditions for clinical trials, this study was to evaluate the effects of different therapeutic programs of H1FU with 1200W/cm_(2) on H22 liver tumors. 73 ICR tumor-bearing mice were divided into a control group and HIFU therapeutic groups. The numbers of pulse were used to define the therapy programs and pulse duration of HIFU with a 1.6MHz focused transducer. The various parameters of tumor growth, histology, and mice nutritional state were used to assess the results of HIFU treatment. The data showed that HIFU had an inhibitory effect on H2: tumor growth in all therapeutic groups. With the same input power, the local effects of tumor removal were dependent upon the pulse duration and numbers of pulse. When the total number of pulses increased within a short time, the inhibitory effect was stronger. However, the nutritional state of animals in this group became worse. It implied that severe stress response and catabolism induced by an increase of HIFU pulse in short time would occur.