碱性成纤维细胞生长因子在宫颈癌中的表达及意义

目的：研究碱性成纤维细胞生长因子(bFGF)在宫颈癌组织中的表达情况，探讨其与子宫颈癌的生长、浸润及转移的关系。方法：用免疫组织化学S-P法检测42例子宫颈癌组织中及5例正常宫颈组织中bFGF的表达情况。结果：bFGF在正常子宫颈鳞状上皮细胞中呈阴性或弱阳性表达，正常组织及肿瘤组织的血管内皮细胞、平滑肌细胞均呈弱阳性表达，肿瘤细胞呈不同程度的阳性表达。bFGF强阳性表达与肿瘤大小、病理分级、临床分期、淋巴结有无转移均有显著相关性(P＜0．05)。结论：bFGF在子宫颈癌组织中的表达与肿瘤的生长、浸润及转移密切相关，可作为反映子宫颈癌生物学行为的指标之一。

EVALUATION OF BASIC FIBROBLAST GROWTH FACTOR IN HUMAN CERVICAL CARAINOMA

Objective: To evaluate the expression of basic fibroblast growth factor (bFGF) in human cervical carcinoma, to clarify the relationship between the expression and invasion, metastasis, prognostic value in human cervical carcinoma. Methods: The expression of bFGF was detected by standard S-P immunohistochemical technique in 42 cases of human cervical carcinoma. Results: Squamous cells in normal cervix were negatively or positively stained. Endothelial cells of vessels and smooth muscle cells in normal and neoplastic tissue were positively stained. Moderately or strongly positive expression of bFGF in tumor cells closely correlated with different tumor sizes, pathological grades, clinical stages and lymphonode metastasis (P < 0.05). Conclusion: bFGF is highly related to growth, invasion and metastasis of human cervical carcinoma,it may be one of the predictors for the biological behavior of human cervical carcinoma.