| MK-801对新生大鼠高氧性肺损伤的保护作用 |
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| 引用本文： | 汤飞鸽,岳少杰,罗自强,冯德云.MK-801对新生大鼠高氧性肺损伤的保护作用[J].临床儿科杂志,2005,23(1):28-30. |
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| 作者姓名： | 汤飞鸽 岳少杰 罗自强 冯德云 |
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| 作者单位： | 中南大学湘雅医院儿科,湖南,长沙,410008;中南大学湘雅医学院生理学系;中南大学湘雅医学院病理学系 |
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| 基金项目： | 国家自然科学基金资助项目(项目编号:30471835)，教育部回国人员启动基金项目，湖南省自然科学基金项目(项目编号:04JJ6018) |
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| 摘 要： | 目的观察谷氨酸(Glu)的NMDA受体拮抗剂MK-801对新生大鼠高氧性肺损伤的影响,探讨Glu在高氧性肺损伤中的可能作用。方法出生12h内的SD新生大鼠随机分为:空气对照组、空气 MK-801组、高氧对照组及高氧 MK-801组。观察持续高氧暴露7d后各组肺湿/干重比(W/D)、支气管肺泡灌洗液(BALF)中白细胞及中性粒细胞数、肺组织及BALF中一氧化氮(NO)含量的变化。结果MK-801可有效地抑制高氧所致新生大鼠肺W/D、BALF中白细胞和中性粒细胞、肺组织和BALF中NO含量的增高。结论MK-801可有效地减轻新生大鼠高氧性肺损伤,提示内源性Glu通过NMDA受体介导,促进NO的产生而加重肺损伤。
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| 关 键 词： | 高氧 肺损伤 一氧化氮 NMDA受体 MK-801 |
| 文章编号： | 1000-3606(2005)01-028-03 |
| 修稿时间： | 2004年11月25 |
Protective effects of MK - 801 on lung injury induced by hyperoxia in neonatal rats |
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| Tang Feige,Yue Shaojie,Luo Ziqiang,Feng Deyun.Protective effects of MK - 801 on lung injury induced by hyperoxia in neonatal rats[J].The Journal of Clinical Pediatrics,2005,23(1):28-30. |
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| Authors: | Tang Feige Yue Shaojie Luo Ziqiang Feng Deyun |
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| Institution: | Tang Feige,Yue Shaojie,Luo Ziqiang,Feng Deyun.Department of Pediatrics,Xiangya Hospital,Central South University,Changsha,Hunan410008 |
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| Abstract: | Objective To investigate the effects of glutamate NMDA receptor antagonist MK-801on lung injury induced by hyperoxia in neonatal rats.Methods Full term rats in12hours after birth were randomly assigned to four groups:air control group,air MK-801group,hyperoxia group and hyperoxia MK-801group.After7days of oxygen exposure,wet-to-dry lung weight(W/D)was measured and bron-chalveolar lavage fluid(BALF)was collected for cell count.Nitric oxide(NO)in lung tissue and BALF was assayed.Results MK-801could inhibit lung W/D,leukocyte and neutrophil in BALF,NO in lung tissue and BALF enhancement induced by hyperoxia.Conclusions MK-801could alleviate lung injury induced by hyperoxia in neonatal rats,suggesing that endogenous glutamate can aggravate lung injury by mediating NMDA receptor and increasing NO production. |
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| Keywords: | hyperoxia lung injury nitric oxide N-methl-D-aspartate receptor MK-801 |
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