高血压患者新发糖尿病与亚临床炎症因子的相关性及机制

目的 探讨原发性高血压(高血压)患者新发糖尿病与亚临床炎症的相关性及机制。方法 筛选伴腹型肥胖的高血压患者60例设为A组，同期观察健康体检者60名设为正常对照组(B组)。对两组人群同时随访观察,为期3年。如伴腹型肥胖高血压患者新发糖尿病设为C组，对3组人群进行空腹血糖、空腹胰岛素水平、餐后2 h血糖、超敏C反应蛋白、纤...

Relevance and mechanism of sub-clinical inflammatory factor and new-onset diabetes in patients with primary hypertension

Objectives To explore the relevance and mechanism of sub-clinical inflammatory factor and new-onset diabetes in patients with primary hypertension. Methods Sixty hypertensive patients with abdominal obesity （group A） and 60 healthy cases （group B） were followed-up for 3 years. If the new-onset diabetes were found in group A, they would be attributed to group C. Content of fasting blood glucose, fasting insulin levels, postprandial 2 h blood glucose, high sensitivity creactive protein （CRP）, fibrinogen （FIB）, tumor necrosis factor alpha （TNF-ct） and peroxisome proliferator- activated receptor （PPAR） gamma expression level were compared among these three groups. Results After followed up for 3 years, 22 cases with new-onset diabetes were found in group A. Eight hypertensive patients with abdominal obesity in group B were also found, and only one new-onset diabetes was found. Content of fasting blood glucose, fasting insulin levels, postprandial 2 h blood glucose, CRP[（4.23±2.2） mg/L vs. （3.62±l.18）mg/L, P〈0.01 ; （4.23±2.2） mg/L vs. （1.74±0.77） rag/L, P〈0.01], FIB[（4.38±0.77） g/L vs. （2.87±0.62） g/L, P〈0.01 ; （4.38±0.77） g/L vs. （2.25±0.58） g/L, P〈0.01] and TNF-a[（10.2±4.3） ng/Lvs. （4.47±1.31） ng/L, P〈0.01; （10.2±4.3） ng/L vs. （2.68±0.78） ng/L, P〈0.01 ] in group C were significantly higher than those in group B and group A, but PPAR gamma expression level in group C was less than that in group B and group A [5.57±0.73 vs.8.52±0.88, P〈0.01;5.57±0.73 vs. 10.44±1.87, P〈0.011, which showed significant difference. Conclusions Chronic inflammation state may be the important risk factors of hypertension patients with type 2 diabetes. Decreasing express of PPAR gamma may be one of the mechanism of chronic inflammation to induce new-onset diabetes.