Modulation of conditioned taste aversion by sodium pentobarbital |
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Authors: | J T Concannon J Freda |
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Affiliation: | Department of Psychology, State University of New York, Binghamton, NY 13901, USA |
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Abstract: | The effects of pentobarbital on the formation and expression of LiCl induced taste aversion were examined using a two-bottle preference test. Rats adapted to restricted fluid intake were offered a 15% sucrose solution 15 min after a pentobarbital or saline injection but prior to post-CS LiCl or control injections. All animals were tested 3 days later in either the same or opposite drug state, and were returned to the conditioning day drug state for a second test. The results showed that pentobarbital in testing disrupted evidence for taste aversion in a manner not simply accounted for by its dipsogenic effects. It was suggested that the present paradigm may prove to be a simple behavioral assay for screening putative anxiolytic drugs. |
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Keywords: | Pentobarbital Conditioned taste aversion Lithium chloride Anxiolytic drugs Conflict tests |
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