Diagnosis of gastrointestinal stromal tumors: a consensus approach |
| |
Authors: | Fletcher Christopher D M Berman Jules J Corless Christopher Gorstein Fred Lasota Jerzy Longley B Jack Miettinen Markku O'Leary Timothy J Remotti Helen Rubin Brian P Shmookler Barry Sobin Leslie H Weiss Sharon W |
| |
Affiliation: | Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston MA 02115, USA. |
| |
Abstract: | As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GIST), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor tyrosine kinase inhibitor STI-571, these tumors have become the focus of considerable attention among pathologists, clinicians, and patients. Stromal/mesenchymal tumors of the gastrointestinal tract have long been a source of confusion and controversy with regard to classification, line(s) of differentiation, and prognostication. Characterization of the KIT pathway and its phenotypic implications has helped to resolve some but not all of these issues. Given the now critical role of accurate and reproducible pathologic diagnosis in ensuring appropriate treatment for patients with GIST, the National Institutes of Health (NIH) convened a GIST workshop in April 2001 with the goal of developing a consensus approach to diagnosis and morphologic prognostication. Key elements of the consensus, as described herein, are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term benign for any GIST, at least at the present time. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|