| 格拉司琼预防颅脑外科手术后恶心呕吐的临床研究 |
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| 关 键 词： | 格拉司琼 预防 颅脑外科 术后 恶心 呕吐 临床研究 药物疗法 |
Clinical observation of granisetron in preventing postoperative nausea and vomiting following supratentorial craniotomy] |
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| Authors: | Yun-jiao Wang Zhi-gang Cheng Qu-lain Guo |
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| Institution: | Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To observe the prophylactic effect of granisetron on postoperative nausea and vomiting (PONV) after supratentorial craniotomy. METHODS: Seventy ASA I-II patients undergoing elective supratentorial craniotomy were randomly and double-bindly divided into two groups: control group (Group C, n = 35) and granisetron group (Group G, n = 35). All the patients received either 0.9% NS (Group C) or granisetron 3 mg (Group G) via intravenous injection. The incidences of postoperative nausea and vomiting were recorded at 24 h, 48 h, 72 h after supratentorial craniotomy. RESULTS: The incidence of PONV in Group G was lower than that in Group C (25.7% vs 57.1%, P < 0.01). The incidence of server nausea with vomiting or vomiting in Group G was lower than that in Group C (17.2% vs 48.6%, P < 0.01). CONCLUSION: Granisetron can be used effectively and safely to prevent PONV in supratentorial craniotomy. |
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