320例伤寒的临床和实验研究

目的为提高伤寒临床诊断水平和选择合理的治疗药物提供依据.方法分析了320例伤寒患者的临床资料,并对其中115株伤寒杆菌作常用药敏检测.结果极其不规则发热占62.8%,肝脾肿大分别占50.6%和54.4%,嗜酸粒细胞消失占72%.并发症中的肠出血占12%,中毒性肝炎占5.9%,中毒性心肌炎占3.4%.伤寒杆菌对抗菌素的耐药性比十年前明显增加(P＜0.01).结论临床经验对伤寒诊断仍具有重要价值.喹诺酮类药物是治疗伤寒的合理选择.

CLINICAL AND LABORATORY STUDIES OF 320 PATIENTS WITH TYPHOID FEVER

Objective To provide evidence in improving the clinical diagnosis level of typhoid and choosing the suitable drugs. Method The clinical data of 320 patients of typhoid were retrospectively analyzed, and the routine drugs sensitivity test to the 115strains of salmonella typhi was taken. Results Most of the patients had no regular fever (62.8%), liver and spleen were enlarged respectively in 50.6% and 54.4 % of the cases, blood, eosinophil, disappeared in 72%. There were intestinal hemorrhage (12%), toxic hepatitis (5.9%) and toxic myocarditis (3.4%) as complications. In the sensitivity test, the number of antibiotics resistantstrains of salmonella typhi was increased more than that seen 10 years ago (P<0.01). Conclusion Clinic experience still plays the key role in the diagnosis of the disease. Quinolones were suitable drugs for the treatment of thphoid.