Estrogen receptor alpha dinucleotide repeat polymorphism in Japanese patients with autoimmune thyroid diseases |
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| Authors: | Yoshiyuki Ban Matsuo Taniyama Teruaki Tozaki Motowo Tomita Yoshio Ban |
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| Affiliation: | (1) Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan;(2) Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan;(3) Department of Molecular Genetics, Laboratory of Racing Chemistry, Tochigi-ken, Japan |
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| Abstract: | Background The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex interactions between predisposing genes and environmental triggers. Susceptibility to AITDs is conferred by genes in the human leukocyte antigen (HLA) and genes unlinked to HLA, including the CTLA-4 gene. Recently, an association to some estrogen receptor (ER)α genotypes with breast cancer, hypertension, osteoporosis, generalized osteoarthritis, and some autoimmune diseases such as rheumatoid arthritis has been reported. We have analyzed a dinucleotide (TA)n repeat polymorphism lying upstream of the human ERα gene in patients with AITDs and in normal subjects. |
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