Evaluation of Quantitative Portal Venous, Hepatic Arterial, and Total Hepatic Tissue Blood Flow Using Xenon CT in Alcoholic Liver Cirrhosis: Comparison With Liver Cirrhosis C |
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Authors: | Hideaki Takahashi Michihiro Suzuki Hiroki Ikeda Minoru Kobayashi Shigeru Sase Hiroshi Yotsuyanagi Shiro Maeyama Shiro Iino Fumio Itoh |
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Institution: | Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki, Japan;;Kitakashiwa Rehabilitation General Hospital, Kashiwa, Japan;;Anzai Medical Company Ltd.;Tokyo, Japan;;Department of internal Medicine, Division of Infectious Diseases, the University of Tokyo, Tokyo, Japan;and;Kiyokawa Hospital, Tokyo, Japan. |
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Abstract: | Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing tissue blood flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis C (C-LC). Methods: Xenon computed tomography was performed on 12 patients with AL-LC and 17 patients with C-LC. The severity of LC was classified according to Child–Pugh classification. Correlations between hepatic TBF and Child–Pugh classification were examined. Correlations of hepatic TBF in Child–Pugh class A to C-LC and AL-LC were also examined. Results: The mean portal venous TBF (PVTBF) was significantly lower in AL-LC than in C-LC ( p =0.0316). Similarly, the mean total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC ( p =0.0390). PVTBF displayed a significant negative correlation with Child–Pugh score ( r =?0.396, p =0.0368). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease. |
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Keywords: | Xenon Computed Tomography Hepatic Tissue Blood Flow Alcoholic Liver Cirrhosis Child–Pugh Classification |
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