大剂量川芎嗪治疗脑梗塞48例

目的：探讨川芎嗪对晚期肺癌患者血小板功能的影响。方法：对２５例晚期肺癌患者和２６例健康对照者测定了血浆血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）、凝血Ⅷ因子活性（Ⅷ：Ｃ）、血管性假血友病因子（ｖＷＦ）、纤维蛋白原（Ｆｇ）、抗凝血酶Ⅲ活性（ＡＴ－Ⅲ：ａ）、抗凝血酶Ⅲ抗原（ＡＴ－Ⅲ：Ａｇ）及血小板粘附功能（ＰＡｄＴ）、血小板聚集功能（ＰＡｇＴ）。并对肺癌患者用川芎嗪（Ｔ

Effects of Tetramethylpyrazine on Platelet Functions of Advanced Cases of Lung Carcinoma

OBJECTIVE: To explore the role of hypercoagulation in the metastasis of carcinoma. METHODS: The effect of Tetramethylpyrazine (TTMP) on platelet functions among the 25 advanced cases of lung carcinoma, and 26 matched control subjects were investigated in the study. Their ages varied from 31-86 years (mean 58.2) in lung carcinoma group (13 male, 12 female) and 36 to 61 (mean 52.9) in the control group (16 male, 10 female). The pathologic types were as follows: 7 cases of squamous cell cancer, 12 adenocarcinoma, 2 small cell carcinoma and 4 undistinguished type. The TNM stage revealed 14 cases in stage IIIa, 3 in stage IIIb and 8 in stage IV. The site of metastasis included mediastinal lymph node, pleura, supraclavicular lymph node, brain, spine, costa, skin and pericardium. The levels of plasma TXB2, 6-keto-PGF1 alpha, VIII:C, vWF, AT-III:a, AT-III:Ag, Fg and blood PAdT, PAgT were measured before and after the intravenous infusion of 80 mg TTMP in patients with lung carcinoma. RESULTS: The levels of TXB2, 6-keto-PGF1 alpha, VIII:C, vWF and Fg in lung carcinoma group were significantly elevated, while the levels of PAdT was greatly decreased, compared with the control group, no significant differences in levels of PAgT, AT-III:a and AT-III:Ag were found between the two groups. After the infusion of TTMP the levels of PAdT, PagT, VIII:C, dWF and Fg were decreased significantly, while TXB2, 6-keto-PGF1 alpha, AT-III:a and AT-III:Ag remained unchanged. CONCLUSIONS: TTMP inhibits the adhesion and aggregatory functions of blood platelet and the activity of coagulation factors. It might be one of the mechanisms of TTMP's antimetastasis of lung carcinoma.