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| 大肠癌患者VEGF和Endostatin的表达及其与临床病理特征的关系 | |
| 引用本文： | 刘福国,冀玉苓,潘新亭,路艳艳,孙学国,高艳景,陈建,江月萍.大肠癌患者VEGF和Endostatin的表达及其与临床病理特征的关系[J].中国现代普通外科进展,2011,14(8):602-605. |
| 作者姓名： | 刘福国 冀玉苓 潘新亭 路艳艳 孙学国 高艳景 陈建 江月萍 |
| 作者单位： | 1. 青岛大学医学院附属医院消化内科,山东青岛,266003 2. 青岛大学医学院附属医院信息科,山东青岛,266003 3. 青岛大学医学院附属医院普外科,山东青岛,266003 4. 山东大学齐鲁医院消化内科,山东济南,250012 |
| 基金项目： | 山东省卫生厅科技资助项目(2001CAICJB9) |
| 摘 要： | 目的：探讨大肠癌患者手术前后血清血管内皮生长因子（VEGF）和Endostatin的动态变化规律及其与临床病理特征的关系。方法：ELISA法检测大肠癌患者（大肠癌组）术前及术后2周血清VEGF和Endostatin水平,并与大肠腺瘤患者（大肠腺瘤组）和健康对照者（对照组）进行比较。结果：1）大肠癌组术前血清VEGF水平显著高于大肠腺瘤组及对照组（P均〈0.01）。2）大肠癌组术前血清Endostatin水平显著高于大肠腺瘤组及对照组（P均〈0.01）。3）大肠癌组术前血清VEGF、Endostatin水平与原发肿瘤大小、细胞分化程度、区域淋巴结转移、肝转移及Dukes分期密切相关（P均〈0.05）,与性别、肿瘤部位等因素无关（P〉0.05）。4）大肠癌组术后2周血清VEGF水平较术前显著下降,而血清Endostatin水平较术前升高（P均〈0.01）。结论：大肠癌患者血清VEGF和Endostatin水平升高,且与原发肿瘤大小、细胞分化程度、区域淋巴结转移、肝脏转移及Dukes分期等因素有密切关系;血清VEGF和Endostatin水平是评价大肠癌恶性行为、预测浸润和转移程度的有效指标。 |
| 关 键 词： | 大肠肿瘤 血管内皮生长因子 Endostatin 酶联免疫吸附试验 |
Serum levels of vascular endothelial growth factor and endostatin expression in colorectal carcinoma patients and the relationships with clinical and pathological characteristics |
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| LIU Fu-guo,JI Yu-ling,Pan Xin-ting,LU Yan-yan,SUN Xue-guo,GAO Yan-jing,CHEN Jian,JIANG Yue-ping.Serum levels of vascular endothelial growth factor and endostatin expression in colorectal carcinoma patients and the relationships with clinical and pathological characteristics[J].Chinese Journal of Current Advances in General Surgery,2011,14(8):602-605. | |
| Authors: | LIU Fu-guo JI Yu-ling Pan Xin-ting LU Yan-yan SUN Xue-guo GAO Yan-jing CHEN Jian JIANG Yue-ping |
| Institution: | LIU Fu-guo1,JI Yu-ling2,Pan Xin-ting3,LU Yan-yan1,SUN Xue-guo1,GAO Yan-jing4,CHEN Jian4,JIANG Yue-ping1 1Department of Gastroenterology,2Department of Information Section,3Department of General Surgery,The Affiliated Hospital of Medical College Qingdao University(Qingdao 266003,China) 4Department of Gastroenterology,Qilu Hospital Shandong University(Jinan 250012,China) |
| Abstract: | Objective: To study the relationship between the serum levels of vascular endothelial growth factor(VEGF),endostatin and clinical and pathological characteristics in colorectal carcinoma patients.Methods: Serum VEGF and endostatin levels were measured by enzyme-linked immunoassay in 58 patients with colorectal carcinoma before and after surgical resection(two weeks later) and in control groups including 30 patients with adenoma of colon and 30 healthy persons.Results: 1)The preoperative serum level of VEGF ... |
| Keywords: | Colorectal carcinoma·Vascular endothelial growth factor·Endostatin·Enzyme-linked immunoassay |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |