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Effects of Canavalia lectins on Acute Inflammation in Sensitized and Non-sensitized Rats |
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| Authors: | Nilson Vieira Pinto Benildo Sousa Cavada Lucas Ferreira Brito Ronniery Ilario Pereira Mayara Torquato Lima da Silva Rondinelle Ribeiro Castro Alana de Freitas Pires Ana Maria Sampaio Assreuy |
| Affiliation: | 1. Institute of Biomedical Sciences, State University of Ceará, Av. Paranjana, 1700, 60740-000, Fortaleza, CE, Brazil 2. Federal Institute of Ceará, Canindé Campus, Rodovia BR 020 Km 303, Jubaia, 62700-000, Canindé, CE, Brazil 3. Department of Biochemistry and Molecular Biology, Federal University of Ceará, Mr. Hull s/n Building 907, 60445-970, Fortaleza, CE, Brazil 4. Faculty of Philosophy Dom Aureliano Matos, State University of Ceará, Av. Dom Aureliano Matos, 2058, Centro, 62930-000, Limoeiro do Norte, CE, Brazil |
| Abstract: | The anti-inflammatory activity of Canavalia seed lectins (Canavalia gladiata [CGL], Canavalia maritima [ConM] and Canavalia brasiliensis [ConBr]) was evaluated by intravenous administration in rats. In non-sensitized rats, cellular edema elicited by carrageenan was reduced (45–51 %) by ConM and (44–59 %) by CGL. Osmotic edema elicited by dextran was reduced by ConM and CGL in 27 % and 29 %. ConM and CGL reduced the edema elicited by l-arginine in 53 % and that of prostaglandin E2 in 48 % and 36 %. Leukocyte migration elicited by carrageenan was reduced in 49 % by ConM and in 55 % by CGL (attenuated in 4× by glucose) and peritoneal TNF-α content in 82 %. In rats sensitized, ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34 % and 70 %. ConM and CGL are anti-inflammatory, mainly in cellular events mediated by prostaglandin E2, nitric oxide and TNF-α in non-sensitized rats. However, only ConM is anti-inflammatory in sensitized rats. CGL effect involves the lectin domain. |
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